Advanced

A critical evaluation of wet biomarkers for huntington's disease : Current status and ways forward

Silajdzic, Edina LU and Bjorkqvist, Maria LU (2018) In Journal of Huntington's disease 7(2). p.109-135
Abstract

There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth... (More)

There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarker, blood, cerebrospinal fluid, Huntington's disease, plasma, saliva, serum, urine
in
Journal of Huntington's disease
volume
7
issue
2
pages
27 pages
publisher
IOS Press
external identifiers
  • pmid:29614689
  • scopus:85048526858
ISSN
1879-6397
DOI
10.3233/JHD-170273
language
English
LU publication?
yes
id
a542b52c-dfae-4530-a48c-24ab8aaf030c
date added to LUP
2018-07-03 11:44:29
date last changed
2020-03-24 06:17:05
@article{a542b52c-dfae-4530-a48c-24ab8aaf030c,
  abstract     = {<p>There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development.</p>},
  author       = {Silajdzic, Edina and Bjorkqvist, Maria},
  issn         = {1879-6397},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {109--135},
  publisher    = {IOS Press},
  series       = {Journal of Huntington's disease},
  title        = {A critical evaluation of wet biomarkers for huntington's disease : Current status and ways forward},
  url          = {http://dx.doi.org/10.3233/JHD-170273},
  doi          = {10.3233/JHD-170273},
  volume       = {7},
  year         = {2018},
}