A critical evaluation of wet biomarkers for huntington's disease : Current status and ways forward
(2018) In Journal of Huntington's disease 7(2). p.109-135- Abstract
There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth... (More)
There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development.
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- author
- Silajdzic, Edina LU and Bjorkqvist, Maria LU
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biomarker, blood, cerebrospinal fluid, Huntington's disease, plasma, saliva, serum, urine
- in
- Journal of Huntington's disease
- volume
- 7
- issue
- 2
- pages
- 27 pages
- publisher
- IOS Press
- external identifiers
-
- pmid:29614689
- scopus:85048526858
- ISSN
- 1879-6397
- DOI
- 10.3233/JHD-170273
- language
- English
- LU publication?
- yes
- id
- a542b52c-dfae-4530-a48c-24ab8aaf030c
- date added to LUP
- 2018-07-03 11:44:29
- date last changed
- 2023-02-08 23:24:29
@article{a542b52c-dfae-4530-a48c-24ab8aaf030c,
abstract = {{<p>There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development.</p>}},
author = {{Silajdzic, Edina and Bjorkqvist, Maria}},
issn = {{1879-6397}},
keywords = {{biomarker; blood; cerebrospinal fluid; Huntington's disease; plasma; saliva; serum; urine}},
language = {{eng}},
month = {{01}},
number = {{2}},
pages = {{109--135}},
publisher = {{IOS Press}},
series = {{Journal of Huntington's disease}},
title = {{A critical evaluation of wet biomarkers for huntington's disease : Current status and ways forward}},
url = {{http://dx.doi.org/10.3233/JHD-170273}},
doi = {{10.3233/JHD-170273}},
volume = {{7}},
year = {{2018}},
}