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Mortality and cancer incidence among women with a high consumption of fatty fish contaminated with persistent organochlorine compounds

Rylander, L LU and Hagmar, L LU (1995) In Scandinavian Journal of Work, Environment and Health 21(6). p.26-419
Abstract

OBJECTIVES: The purpose of this study was to assess cancer incidence and cardiovascular mortality among women with a high dietary intake of fatty fish from the Baltic Sea (on the Swedish east coast), contaminated with persistent organochlorine compounds.

MATERIAL AND METHODS: Cohorts of fishermen's wives from the Swedish east (1989 subjects) and west (6605 subjects) coasts were established. The mortality and cancer incidence were studied in these cohorts, and comparisons were made with respective regional populations and between the cohorts. Dietary interviews were made with 200 randomly selected cohort women and equally many women from the general population. The interviewed east- and westcoast cohort women ate locally caught... (More)

OBJECTIVES: The purpose of this study was to assess cancer incidence and cardiovascular mortality among women with a high dietary intake of fatty fish from the Baltic Sea (on the Swedish east coast), contaminated with persistent organochlorine compounds.

MATERIAL AND METHODS: Cohorts of fishermen's wives from the Swedish east (1989 subjects) and west (6605 subjects) coasts were established. The mortality and cancer incidence were studied in these cohorts, and comparisons were made with respective regional populations and between the cohorts. Dietary interviews were made with 200 randomly selected cohort women and equally many women from the general population. The interviewed east- and westcoast cohort women ate locally caught fatty fish at least twice as often as their referents.

RESULTS: Compared with that of the regional population, the breast cancer incidence was higher than expected in the eastcoast cohort [standardized incidence ratio (SIR) 1.29, 95% confidence interval (95% CI) 0.96-1.71], whereas it was lower in the westcoast cohort (SIR 0.89; 95% CI 0.77-1.04). When a direct comparison was made between the two cohorts, the eastcoast women displayed an increased breast cancer incidence (incidence rate ratio 1.35, 95% CI 0.98-1.86). No obvious difference was seen between the two cohorts concerning cardiovascular mortality.

CONCLUSIONS: The results support, but do not prove, the hypothesis of an association between exposure to a mixture of persistent organochlorine compounds through fish consumption and an increased risk for breast cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Animals, Cardiovascular Diseases/epidemiology, Cause of Death, Cohort Studies, Diet, Female, Fishes, Food Contamination, Food-Processing Industry, Humans, Hydrocarbons, Chlorinated/adverse effects, Incidence, Middle Aged, Neoplasms/epidemiology, Sweden/epidemiology
in
Scandinavian Journal of Work, Environment and Health
volume
21
issue
6
pages
26 - 419
publisher
Finnish Institute of Occupational Health
external identifiers
  • scopus:0029415856
ISSN
0355-3140
DOI
10.5271/sjweh.57
language
English
LU publication?
yes
id
a577a194-050c-47a4-b245-29c35bcfbdf9
date added to LUP
2018-08-27 14:00:03
date last changed
2018-10-03 11:29:33
@article{a577a194-050c-47a4-b245-29c35bcfbdf9,
  abstract     = {<p>OBJECTIVES: The purpose of this study was to assess cancer incidence and cardiovascular mortality among women with a high dietary intake of fatty fish from the Baltic Sea (on the Swedish east coast), contaminated with persistent organochlorine compounds.</p><p>MATERIAL AND METHODS: Cohorts of fishermen's wives from the Swedish east (1989 subjects) and west (6605 subjects) coasts were established. The mortality and cancer incidence were studied in these cohorts, and comparisons were made with respective regional populations and between the cohorts. Dietary interviews were made with 200 randomly selected cohort women and equally many women from the general population. The interviewed east- and westcoast cohort women ate locally caught fatty fish at least twice as often as their referents.</p><p>RESULTS: Compared with that of the regional population, the breast cancer incidence was higher than expected in the eastcoast cohort [standardized incidence ratio (SIR) 1.29, 95% confidence interval (95% CI) 0.96-1.71], whereas it was lower in the westcoast cohort (SIR 0.89; 95% CI 0.77-1.04). When a direct comparison was made between the two cohorts, the eastcoast women displayed an increased breast cancer incidence (incidence rate ratio 1.35, 95% CI 0.98-1.86). No obvious difference was seen between the two cohorts concerning cardiovascular mortality.</p><p>CONCLUSIONS: The results support, but do not prove, the hypothesis of an association between exposure to a mixture of persistent organochlorine compounds through fish consumption and an increased risk for breast cancer.</p>},
  author       = {Rylander, L and Hagmar, L},
  issn         = {0355-3140},
  keyword      = {Adult,Animals,Cardiovascular Diseases/epidemiology,Cause of Death,Cohort Studies,Diet,Female,Fishes,Food Contamination,Food-Processing Industry,Humans,Hydrocarbons, Chlorinated/adverse effects,Incidence,Middle Aged,Neoplasms/epidemiology,Sweden/epidemiology},
  language     = {eng},
  number       = {6},
  pages        = {26--419},
  publisher    = {Finnish Institute of Occupational Health},
  series       = {Scandinavian Journal of Work, Environment and Health},
  title        = {Mortality and cancer incidence among women with a high consumption of fatty fish contaminated with persistent organochlorine compounds},
  url          = {http://dx.doi.org/10.5271/sjweh.57},
  volume       = {21},
  year         = {1995},
}