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Cost-effectiveness analysis of budesonide/formoterol compared with fluticasone in moderate-persistent asthma

Ericsson, Karin ; Bantje, T. A. ; Huber, R. M. ; Borg, S. LU and Bateman, E. D. (2006) In Respiratory Medicine 100(4). p.586-594
Abstract

In this economic evaluation, conducted alongside a randomized, double-blind clinical trial, economic data were collected from 339 patients with moderate-persistent asthma randomized to receive twice-daily, double-blind treatment with budesonide/formoterol 160/4.5 μg in a single inhaler (n = 166) or fluticasone propionate 250 μg (n = 173) for 12 weeks. The mean number of episode-free days (EFD) per patient was significantly greater in the budesonide/formoterol group than the fluticasone group (48.71 compared with 42.34, P = 0.0185). Data on medication use, visits to healthcare professionals, and hospitalization were pooled across all six countries and combined with German and Dutch unit cost data to calculate total healthcare costs.... (More)

In this economic evaluation, conducted alongside a randomized, double-blind clinical trial, economic data were collected from 339 patients with moderate-persistent asthma randomized to receive twice-daily, double-blind treatment with budesonide/formoterol 160/4.5 μg in a single inhaler (n = 166) or fluticasone propionate 250 μg (n = 173) for 12 weeks. The mean number of episode-free days (EFD) per patient was significantly greater in the budesonide/formoterol group than the fluticasone group (48.71 compared with 42.34, P = 0.0185). Data on medication use, visits to healthcare professionals, and hospitalization were pooled across all six countries and combined with German and Dutch unit cost data to calculate total healthcare costs. Using German unit costs, budesonide/formoterol was associated with significantly lower total healthcare costs per patient over the 12-week period compared with fluticasone (€131 compared with €210, P = 0.0043). Using Dutch unit costs, total healthcare costs were slightly numerically lower in the budesonide/formoterol group than the fluticasone group (€102 compared with €104), but the difference did not reach statistical significance. Budesonide/formoterol in a single inhaler is more effective than a higher microgram dose of fluticasone alone. It is cost-neutral and may provide cost-savings in some countries.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Asthma, Budesonide/formoterol, Cost-effectiveness, Fluticasone
in
Respiratory Medicine
volume
100
issue
4
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:33344469686
  • pmid:16274980
ISSN
0954-6111
DOI
10.1016/j.rmed.2005.09.032
language
English
LU publication?
no
id
a578649a-da93-4b5b-aa5f-97bcf91b49f2
date added to LUP
2018-10-20 11:28:03
date last changed
2020-01-13 01:05:04
@article{a578649a-da93-4b5b-aa5f-97bcf91b49f2,
  abstract     = {<p>In this economic evaluation, conducted alongside a randomized, double-blind clinical trial, economic data were collected from 339 patients with moderate-persistent asthma randomized to receive twice-daily, double-blind treatment with budesonide/formoterol 160/4.5 μg in a single inhaler (n = 166) or fluticasone propionate 250 μg (n = 173) for 12 weeks. The mean number of episode-free days (EFD) per patient was significantly greater in the budesonide/formoterol group than the fluticasone group (48.71 compared with 42.34, P = 0.0185). Data on medication use, visits to healthcare professionals, and hospitalization were pooled across all six countries and combined with German and Dutch unit cost data to calculate total healthcare costs. Using German unit costs, budesonide/formoterol was associated with significantly lower total healthcare costs per patient over the 12-week period compared with fluticasone (€131 compared with €210, P = 0.0043). Using Dutch unit costs, total healthcare costs were slightly numerically lower in the budesonide/formoterol group than the fluticasone group (€102 compared with €104), but the difference did not reach statistical significance. Budesonide/formoterol in a single inhaler is more effective than a higher microgram dose of fluticasone alone. It is cost-neutral and may provide cost-savings in some countries.</p>},
  author       = {Ericsson, Karin and Bantje, T. A. and Huber, R. M. and Borg, S. and Bateman, E. D.},
  issn         = {0954-6111},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {586--594},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Cost-effectiveness analysis of budesonide/formoterol compared with fluticasone in moderate-persistent asthma},
  url          = {http://dx.doi.org/10.1016/j.rmed.2005.09.032},
  doi          = {10.1016/j.rmed.2005.09.032},
  volume       = {100},
  year         = {2006},
}