Molecular mechanisms governing aquaporin relocalisation
(2022) In Biochimica et Biophysica Acta - Biomembranes 1864(4).- Abstract
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs has made little progress due to a lack of reproducible high-throughput assays and difficulties with the druggability of AQP proteins. However, recent studies have suggested that targetting the trafficking of AQP proteins to the plasma... (More)
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs has made little progress due to a lack of reproducible high-throughput assays and difficulties with the druggability of AQP proteins. However, recent studies have suggested that targetting the trafficking of AQP proteins to the plasma membrane is a viable alternative drug target to direct inhibition of the water-conducting pore. Here we review the literature on the trafficking of mammalian AQPs with a view to highlighting potential new drug targets for a variety of conditions associated with disrupted water and solute homeostasis.
(Less)
- author
- organization
- publishing date
- 2022-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AQP, Aquaporin, Membrane trafficking, Osmosis
- in
- Biochimica et Biophysica Acta - Biomembranes
- volume
- 1864
- issue
- 4
- article number
- 183853
- publisher
- Elsevier
- external identifiers
-
- pmid:34973181
- scopus:85123175947
- ISSN
- 0005-2736
- DOI
- 10.1016/j.bbamem.2021.183853
- language
- English
- LU publication?
- yes
- id
- a59fc8d9-cb05-487d-b42e-e4a318346b39
- date added to LUP
- 2022-04-04 13:18:27
- date last changed
- 2025-02-10 13:33:19
@article{a59fc8d9-cb05-487d-b42e-e4a318346b39, abstract = {{<p>The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs has made little progress due to a lack of reproducible high-throughput assays and difficulties with the druggability of AQP proteins. However, recent studies have suggested that targetting the trafficking of AQP proteins to the plasma membrane is a viable alternative drug target to direct inhibition of the water-conducting pore. Here we review the literature on the trafficking of mammalian AQPs with a view to highlighting potential new drug targets for a variety of conditions associated with disrupted water and solute homeostasis.</p>}}, author = {{Markou, Andrea and Unger, Lucas and Abir-Awan, Mohammed and Saadallah, Ahmed and Halsey, Andrea and Baklava, Zita and Conner, Matthew and Törnroth-Horsefield, Susanna and Greenhill, Stuart D. and Conner, Alex and Bill, Roslyn M. and Salman, Mootaz M. and Kitchen, Philip}}, issn = {{0005-2736}}, keywords = {{AQP; Aquaporin; Membrane trafficking; Osmosis}}, language = {{eng}}, month = {{04}}, number = {{4}}, publisher = {{Elsevier}}, series = {{Biochimica et Biophysica Acta - Biomembranes}}, title = {{Molecular mechanisms governing aquaporin relocalisation}}, url = {{http://dx.doi.org/10.1016/j.bbamem.2021.183853}}, doi = {{10.1016/j.bbamem.2021.183853}}, volume = {{1864}}, year = {{2022}}, }