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Molecular mechanisms governing aquaporin relocalisation

Markou, Andrea ; Unger, Lucas ; Abir-Awan, Mohammed ; Saadallah, Ahmed ; Halsey, Andrea ; Baklava, Zita ; Conner, Matthew ; Törnroth-Horsefield, Susanna LU ; Greenhill, Stuart D. and Conner, Alex , et al. (2022) In Biochimica et Biophysica Acta - Biomembranes 1864(4).
Abstract

The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs has made little progress due to a lack of reproducible high-throughput assays and difficulties with the druggability of AQP proteins. However, recent studies have suggested that targetting the trafficking of AQP proteins to the plasma... (More)

The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs has made little progress due to a lack of reproducible high-throughput assays and difficulties with the druggability of AQP proteins. However, recent studies have suggested that targetting the trafficking of AQP proteins to the plasma membrane is a viable alternative drug target to direct inhibition of the water-conducting pore. Here we review the literature on the trafficking of mammalian AQPs with a view to highlighting potential new drug targets for a variety of conditions associated with disrupted water and solute homeostasis.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AQP, Aquaporin, Membrane trafficking, Osmosis
in
Biochimica et Biophysica Acta - Biomembranes
volume
1864
issue
4
article number
183853
publisher
Elsevier
external identifiers
  • scopus:85123175947
  • pmid:34973181
ISSN
0005-2736
DOI
10.1016/j.bbamem.2021.183853
language
English
LU publication?
yes
id
a59fc8d9-cb05-487d-b42e-e4a318346b39
date added to LUP
2022-04-04 13:18:27
date last changed
2024-06-16 14:06:15
@article{a59fc8d9-cb05-487d-b42e-e4a318346b39,
  abstract     = {{<p>The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs has made little progress due to a lack of reproducible high-throughput assays and difficulties with the druggability of AQP proteins. However, recent studies have suggested that targetting the trafficking of AQP proteins to the plasma membrane is a viable alternative drug target to direct inhibition of the water-conducting pore. Here we review the literature on the trafficking of mammalian AQPs with a view to highlighting potential new drug targets for a variety of conditions associated with disrupted water and solute homeostasis.</p>}},
  author       = {{Markou, Andrea and Unger, Lucas and Abir-Awan, Mohammed and Saadallah, Ahmed and Halsey, Andrea and Baklava, Zita and Conner, Matthew and Törnroth-Horsefield, Susanna and Greenhill, Stuart D. and Conner, Alex and Bill, Roslyn M. and Salman, Mootaz M. and Kitchen, Philip}},
  issn         = {{0005-2736}},
  keywords     = {{AQP; Aquaporin; Membrane trafficking; Osmosis}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta - Biomembranes}},
  title        = {{Molecular mechanisms governing aquaporin relocalisation}},
  url          = {{http://dx.doi.org/10.1016/j.bbamem.2021.183853}},
  doi          = {{10.1016/j.bbamem.2021.183853}},
  volume       = {{1864}},
  year         = {{2022}},
}