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A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia

Lazarevic, Vladimir Lj LU ; Tomin, Dragica; Jankovic, Gradimir M; Antic, Darko; Dencic, Marija; Gotic, Mirjana and Boskovic, Darinka (2004) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 148(1). p.9-77
Abstract

A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Aged, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 2, Humans, Leukemia, Myeloid, Acute, Male, Thrombocythemia, Essential, Translocation, Genetic
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
148
issue
1
pages
3 pages
publisher
Elsevier
external identifiers
  • Scopus:0347511684
ISSN
0165-4608
DOI
10.1016/S0165-4608(03)00215-2
language
English
LU publication?
no
id
a5b9b18b-3234-4bd5-82ff-6c8a40177a2e
date added to LUP
2016-05-24 17:23:53
date last changed
2017-02-02 11:54:14
@article{a5b9b18b-3234-4bd5-82ff-6c8a40177a2e,
  abstract     = {<p>A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.</p>},
  author       = {Lazarevic, Vladimir Lj and Tomin, Dragica and Jankovic, Gradimir M and Antic, Darko and Dencic, Marija and Gotic, Mirjana and Boskovic, Darinka},
  issn         = {0165-4608},
  keyword      = {Aged,Chromosomes, Human, Pair 17,Chromosomes, Human, Pair 2,Humans,Leukemia, Myeloid, Acute,Male,Thrombocythemia, Essential,Translocation, Genetic},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {9--77},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia},
  url          = {http://dx.doi.org/10.1016/S0165-4608(03)00215-2},
  volume       = {148},
  year         = {2004},
}