Effects of renal failure on skeletal muscle
(1993) In Nephron 63(4). p.395-399- Abstract
In this cross-sectional study, we examined biopsies from the vastus lateralis muscle of 13 predialytic uremic men (mean age 46 ± 8 years). Their average glomerular filtration rate was 14 ± 7 ml/min x 1.73 m2 and their maximal exercise capacity, measured by standardized exercise test on a bicycle ergometer, was 184 ± 45 W (94% of the expected norm). The proportion of type I fibers (type I%) in the uremic group was similar to that of the reference group (42 ± 11 vs. 41 ± 8% NS). The proportion of type IIA fibers (type IIA%) in the uremic group was higher than in the reference group (44±10 compared to 35±9%, p2, NS). Type IIA and type I IB fiber areas tended to be smaller than those of the reference group (type IIA fiber area:... (More)
In this cross-sectional study, we examined biopsies from the vastus lateralis muscle of 13 predialytic uremic men (mean age 46 ± 8 years). Their average glomerular filtration rate was 14 ± 7 ml/min x 1.73 m2 and their maximal exercise capacity, measured by standardized exercise test on a bicycle ergometer, was 184 ± 45 W (94% of the expected norm). The proportion of type I fibers (type I%) in the uremic group was similar to that of the reference group (42 ± 11 vs. 41 ± 8% NS). The proportion of type IIA fibers (type IIA%) in the uremic group was higher than in the reference group (44±10 compared to 35±9%, p2, NS). Type IIA and type I IB fiber areas tended to be smaller than those of the reference group (type IIA fiber area: 4,515 ± 929 vs. 5,213 ± 1,288 μm2, NS; type IIB fiber area: 3,953 ± 1,066 vs. 4,406 ± 1,582 μm2, NS) with a type IIA area/type I area ratio which was significantly lower than in the reference group. Citrate synthase activity was 0.48 ± 0.08 μkat/g in the uremic group and 0.50 ± 0.08 μkat/g in the reference group, NS. Phosphofructokinase activity was 1.2 ± 0.5 μkat/g in the uremic group and 1.1 ± 0.3 μkat/g in the reference group, NS. Maximal exercise capacity showed a positive correlation to type 1% (r=0.71, p
(Less)
- author
- Clyne, N. LU ; Esbjornsson, M. ; Jansson, E. ; Jogestrand, T. ; Lins, L. E. and Pehrsson, S. K.
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Maximal exercise capacity, Mitochondrial enzymes, Moderate uremia, Muscle fiber composition
- in
- Nephron
- volume
- 63
- issue
- 4
- pages
- 5 pages
- publisher
- Karger
- external identifiers
-
- scopus:0027535338
- pmid:8459873
- ISSN
- 0028-2766
- language
- English
- LU publication?
- no
- id
- a5f105a9-495d-4de4-bcde-f8f03b2c21c1
- date added to LUP
- 2016-08-30 22:03:52
- date last changed
- 2024-06-01 15:07:22
@article{a5f105a9-495d-4de4-bcde-f8f03b2c21c1, abstract = {{<p>In this cross-sectional study, we examined biopsies from the vastus lateralis muscle of 13 predialytic uremic men (mean age 46 ± 8 years). Their average glomerular filtration rate was 14 ± 7 ml/min x 1.73 m<sup>2</sup> and their maximal exercise capacity, measured by standardized exercise test on a bicycle ergometer, was 184 ± 45 W (94% of the expected norm). The proportion of type I fibers (type I%) in the uremic group was similar to that of the reference group (42 ± 11 vs. 41 ± 8% NS). The proportion of type IIA fibers (type IIA%) in the uremic group was higher than in the reference group (44±10 compared to 35±9%, p2, NS). Type IIA and type I IB fiber areas tended to be smaller than those of the reference group (type IIA fiber area: 4,515 ± 929 vs. 5,213 ± 1,288 μm<sup>2</sup>, NS; type IIB fiber area: 3,953 ± 1,066 vs. 4,406 ± 1,582 μm<sup>2</sup>, NS) with a type IIA area/type I area ratio which was significantly lower than in the reference group. Citrate synthase activity was 0.48 ± 0.08 μkat/g in the uremic group and 0.50 ± 0.08 μkat/g in the reference group, NS. Phosphofructokinase activity was 1.2 ± 0.5 μkat/g in the uremic group and 1.1 ± 0.3 μkat/g in the reference group, NS. Maximal exercise capacity showed a positive correlation to type 1% (r=0.71, p</p>}}, author = {{Clyne, N. and Esbjornsson, M. and Jansson, E. and Jogestrand, T. and Lins, L. E. and Pehrsson, S. K.}}, issn = {{0028-2766}}, keywords = {{Maximal exercise capacity; Mitochondrial enzymes; Moderate uremia; Muscle fiber composition}}, language = {{eng}}, number = {{4}}, pages = {{395--399}}, publisher = {{Karger}}, series = {{Nephron}}, title = {{Effects of renal failure on skeletal muscle}}, volume = {{63}}, year = {{1993}}, }