Hepatitis C virus genotypes among blood donors and their recipients in Iceland determined by the polymerase chain reaction
(1995) In Vox Sanguinis 69(1). p.18-22- Abstract
- Eight antibody-positive individuals were detected among 12,000 blood donations during the first year of screening blood donors for hepatitis C virus (HCV) antibodies in Iceland. All 8 were found to have a history of intravenous drug abuse. Six of these 8 individuals had previously donated blood to 27 patients who could be traced and examined for HCV infection. The great majority (23/27, 85%) of the recipients had demonstrable HCV antibodies. Furthermore, RNA analysis with the polymerase chain reaction showed that all patients with HCV antibodies had HCV RNA in their serum and in one hemodialysis patient without HCV antibodies viral RNA could be demonstrated. Genotyping of the HCV strains showed that the genotype of the donor was also... (More)
- Eight antibody-positive individuals were detected among 12,000 blood donations during the first year of screening blood donors for hepatitis C virus (HCV) antibodies in Iceland. All 8 were found to have a history of intravenous drug abuse. Six of these 8 individuals had previously donated blood to 27 patients who could be traced and examined for HCV infection. The great majority (23/27, 85%) of the recipients had demonstrable HCV antibodies. Furthermore, RNA analysis with the polymerase chain reaction showed that all patients with HCV antibodies had HCV RNA in their serum and in one hemodialysis patient without HCV antibodies viral RNA could be demonstrated. Genotyping of the HCV strains showed that the genotype of the donor was also identified in all but one of the infected recipients of his/her blood or blood products. This study, therefore, substantiates high infectivity of the HCV by blood or blood factor donation and shows that viremic HCV antibody-negative individuals exist. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108844
- author
- Love, A ; Smaradottir, A ; Thorsteinsson, S B ; Stanzeit, B and Widell, Anders LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Vox Sanguinis
- volume
- 69
- issue
- 1
- pages
- 18 - 22
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:7483487
- scopus:0029041851
- ISSN
- 1423-0410
- language
- English
- LU publication?
- yes
- id
- a60da96e-f620-4805-846b-d790b975c8dc (old id 1108844)
- date added to LUP
- 2016-04-01 16:30:12
- date last changed
- 2021-01-03 07:05:09
@article{a60da96e-f620-4805-846b-d790b975c8dc,
abstract = {{Eight antibody-positive individuals were detected among 12,000 blood donations during the first year of screening blood donors for hepatitis C virus (HCV) antibodies in Iceland. All 8 were found to have a history of intravenous drug abuse. Six of these 8 individuals had previously donated blood to 27 patients who could be traced and examined for HCV infection. The great majority (23/27, 85%) of the recipients had demonstrable HCV antibodies. Furthermore, RNA analysis with the polymerase chain reaction showed that all patients with HCV antibodies had HCV RNA in their serum and in one hemodialysis patient without HCV antibodies viral RNA could be demonstrated. Genotyping of the HCV strains showed that the genotype of the donor was also identified in all but one of the infected recipients of his/her blood or blood products. This study, therefore, substantiates high infectivity of the HCV by blood or blood factor donation and shows that viremic HCV antibody-negative individuals exist.}},
author = {{Love, A and Smaradottir, A and Thorsteinsson, S B and Stanzeit, B and Widell, Anders}},
issn = {{1423-0410}},
language = {{eng}},
number = {{1}},
pages = {{18--22}},
publisher = {{Wiley-Blackwell}},
series = {{Vox Sanguinis}},
title = {{Hepatitis C virus genotypes among blood donors and their recipients in Iceland determined by the polymerase chain reaction}},
volume = {{69}},
year = {{1995}},
}