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CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum

Isinger Ekstrand, Anna LU ; Bhat, M LU ; Borg, Åke LU and Nilbert, Mef LU (2006) In BMC Cancer 6.
Abstract
Background: Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer. Methods: We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors. Results: Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly... (More)
Background: Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer. Methods: We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors. Results: Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly different (p = 0.26) from the 1% (3/300) carriers identified in the control group. Conclusion: In summary, our data suggest that the CHEK2 1100delC is not a major cause of double primary breast and colorectal cancer in Sweden, which suggests that this patient group should not routinely be screened for the CHEK2 1100delC variant. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
6
publisher
BioMed Central
external identifiers
  • wos:000236547000003
  • pmid:16539695
  • scopus:33645471674
ISSN
1471-2407
DOI
10.1186/1471-2407-6-64
language
English
LU publication?
yes
id
a64f2564-4a40-488d-8f36-c4ec987f4a34 (old id 908739)
date added to LUP
2008-01-10 07:45:19
date last changed
2018-05-29 09:20:02
@article{a64f2564-4a40-488d-8f36-c4ec987f4a34,
  abstract     = {Background: Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer. Methods: We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors. Results: Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly different (p = 0.26) from the 1% (3/300) carriers identified in the control group. Conclusion: In summary, our data suggest that the CHEK2 1100delC is not a major cause of double primary breast and colorectal cancer in Sweden, which suggests that this patient group should not routinely be screened for the CHEK2 1100delC variant.},
  articleno    = {64},
  author       = {Isinger Ekstrand, Anna and Bhat, M and Borg, Åke and Nilbert, Mef},
  issn         = {1471-2407},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Cancer},
  title        = {CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum},
  url          = {http://dx.doi.org/10.1186/1471-2407-6-64},
  volume       = {6},
  year         = {2006},
}