Diverse polyketides and alkaloids from Penicillium sp. KHMM : structural elucidation, biological and molecular docking studies
Hamed, Abdelaaty ; Ismail, Mohamed LU
; El-Metwally, Mohammad M.
; Frese, Marcel
; Ibrahim, Tarek M.A.
; El-Haddad, Atef F.
; Sewald, Norbert
and Shaaban, Mohamed
(2019)
In Zeitschrift fur Naturforschung - Section C Journal of Biosciences
74(5-6).
p.131-137
- Abstract
As a continuation of our earlier research concerning the investigation of microbial bioactive secondary metabolites from the terrestrial Penicillium sp.KH Link 1809 isolate KHMM, the fungus was re-cultivated on a large scale to explore its bioactive compounds intensively. Fifteen compounds, including seven alkaloids (1-7), one sesquiterpene (8), an acetylenic system (9), two sterols, and sphengolipid, were identified. Their structures were established on the bases of extensive one- and two-dimensional nuclear magnetic resonance and mass measurements, and by comparison with literature data. The antimicrobial activity of the fungal extract and the corresponding compounds were studied using a panel of pathogenic microorganisms, and their... (More)
As a continuation of our earlier research concerning the investigation of microbial bioactive secondary metabolites from the terrestrial Penicillium sp.KH Link 1809 isolate KHMM, the fungus was re-cultivated on a large scale to explore its bioactive compounds intensively. Fifteen compounds, including seven alkaloids (1-7), one sesquiterpene (8), an acetylenic system (9), two sterols, and sphengolipid, were identified. Their structures were established on the bases of extensive one- and two-dimensional nuclear magnetic resonance and mass measurements, and by comparison with literature data. The antimicrobial activity of the fungal extract and the corresponding compounds were studied using a panel of pathogenic microorganisms, and their in vitro cytotoxicity against the human cervix carcinoma cell line (KB-3-1) was reported as well. The molecular docking of the isolated compounds showed promising affinities for the alkaloidal compounds 4-6 towards α, β tubulins.
(Less)
- author
- Hamed, Abdelaaty
; Ismail, Mohamed
LU
; El-Metwally, Mohammad M.
; Frese, Marcel
; Ibrahim, Tarek M.A.
; El-Haddad, Atef F.
; Sewald, Norbert
and Shaaban, Mohamed
- publishing date
- 2019-05-01
- type
- Contribution to journal
- publication status
- published
- keywords
- biological properties, mol-docking, Penicillium sp., polyketide-alkaloides, α, β tubulins
- in
- Zeitschrift fur Naturforschung - Section C Journal of Biosciences
- volume
- 74
- issue
- 5-6
- pages
- 7 pages
- publisher
- Verlag der Zeitschrift für Naturforschung
- external identifiers
-
- pmid:30645191
- scopus:85060005423
- ISSN
- 0939-5075
- DOI
- 10.1515/znc-2018-0145
- language
- English
- LU publication?
- no
- id
- a65ff4d7-5af8-4ff4-b839-1bbe49a56ee2
- date added to LUP
- 2023-08-28 11:45:15
- date last changed
- 2024-04-20 02:03:13
@article{a65ff4d7-5af8-4ff4-b839-1bbe49a56ee2,
abstract = {{<p>As a continuation of our earlier research concerning the investigation of microbial bioactive secondary metabolites from the terrestrial Penicillium sp.KH Link 1809 isolate KHMM, the fungus was re-cultivated on a large scale to explore its bioactive compounds intensively. Fifteen compounds, including seven alkaloids (1-7), one sesquiterpene (8), an acetylenic system (9), two sterols, and sphengolipid, were identified. Their structures were established on the bases of extensive one- and two-dimensional nuclear magnetic resonance and mass measurements, and by comparison with literature data. The antimicrobial activity of the fungal extract and the corresponding compounds were studied using a panel of pathogenic microorganisms, and their in vitro cytotoxicity against the human cervix carcinoma cell line (KB-3-1) was reported as well. The molecular docking of the isolated compounds showed promising affinities for the alkaloidal compounds 4-6 towards α, β tubulins.</p>}},
author = {{Hamed, Abdelaaty and Ismail, Mohamed and El-Metwally, Mohammad M. and Frese, Marcel and Ibrahim, Tarek M.A. and El-Haddad, Atef F. and Sewald, Norbert and Shaaban, Mohamed}},
issn = {{0939-5075}},
keywords = {{biological properties; mol-docking; Penicillium sp.; polyketide-alkaloides; α; β tubulins}},
language = {{eng}},
month = {{05}},
number = {{5-6}},
pages = {{131--137}},
publisher = {{Verlag der Zeitschrift für Naturforschung}},
series = {{Zeitschrift fur Naturforschung - Section C Journal of Biosciences}},
title = {{Diverse polyketides and alkaloids from <i>Penicillium</i> sp. KHMM : structural elucidation, biological and molecular docking studies}},
url = {{http://dx.doi.org/10.1515/znc-2018-0145}},
doi = {{10.1515/znc-2018-0145}},
volume = {{74}},
year = {{2019}},
}