Diverse polyketides and alkaloids from Penicillium sp. KHMM : structural elucidation, biological and molecular docking studies
(2019) In Zeitschrift fur Naturforschung - Section C Journal of Biosciences 74(5-6). p.131-137- Abstract
As a continuation of our earlier research concerning the investigation of microbial bioactive secondary metabolites from the terrestrial Penicillium sp.KH Link 1809 isolate KHMM, the fungus was re-cultivated on a large scale to explore its bioactive compounds intensively. Fifteen compounds, including seven alkaloids (1-7), one sesquiterpene (8), an acetylenic system (9), two sterols, and sphengolipid, were identified. Their structures were established on the bases of extensive one- and two-dimensional nuclear magnetic resonance and mass measurements, and by comparison with literature data. The antimicrobial activity of the fungal extract and the corresponding compounds were studied using a panel of pathogenic microorganisms, and their... (More)
As a continuation of our earlier research concerning the investigation of microbial bioactive secondary metabolites from the terrestrial Penicillium sp.KH Link 1809 isolate KHMM, the fungus was re-cultivated on a large scale to explore its bioactive compounds intensively. Fifteen compounds, including seven alkaloids (1-7), one sesquiterpene (8), an acetylenic system (9), two sterols, and sphengolipid, were identified. Their structures were established on the bases of extensive one- and two-dimensional nuclear magnetic resonance and mass measurements, and by comparison with literature data. The antimicrobial activity of the fungal extract and the corresponding compounds were studied using a panel of pathogenic microorganisms, and their in vitro cytotoxicity against the human cervix carcinoma cell line (KB-3-1) was reported as well. The molecular docking of the isolated compounds showed promising affinities for the alkaloidal compounds 4-6 towards α, β tubulins.
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- author
- Hamed, Abdelaaty ; Ismail, Mohamed LU ; El-Metwally, Mohammad M. ; Frese, Marcel ; Ibrahim, Tarek M.A. ; El-Haddad, Atef F. ; Sewald, Norbert and Shaaban, Mohamed
- publishing date
- 2019-05-01
- type
- Contribution to journal
- publication status
- published
- keywords
- biological properties, mol-docking, Penicillium sp., polyketide-alkaloides, α, β tubulins
- in
- Zeitschrift fur Naturforschung - Section C Journal of Biosciences
- volume
- 74
- issue
- 5-6
- pages
- 7 pages
- publisher
- Verlag der Zeitschrift für Naturforschung
- external identifiers
-
- scopus:85060005423
- pmid:30645191
- ISSN
- 0939-5075
- DOI
- 10.1515/znc-2018-0145
- language
- English
- LU publication?
- no
- id
- a65ff4d7-5af8-4ff4-b839-1bbe49a56ee2
- date added to LUP
- 2023-08-28 11:45:15
- date last changed
- 2024-07-13 09:35:19
@article{a65ff4d7-5af8-4ff4-b839-1bbe49a56ee2, abstract = {{<p>As a continuation of our earlier research concerning the investigation of microbial bioactive secondary metabolites from the terrestrial Penicillium sp.KH Link 1809 isolate KHMM, the fungus was re-cultivated on a large scale to explore its bioactive compounds intensively. Fifteen compounds, including seven alkaloids (1-7), one sesquiterpene (8), an acetylenic system (9), two sterols, and sphengolipid, were identified. Their structures were established on the bases of extensive one- and two-dimensional nuclear magnetic resonance and mass measurements, and by comparison with literature data. The antimicrobial activity of the fungal extract and the corresponding compounds were studied using a panel of pathogenic microorganisms, and their in vitro cytotoxicity against the human cervix carcinoma cell line (KB-3-1) was reported as well. The molecular docking of the isolated compounds showed promising affinities for the alkaloidal compounds 4-6 towards α, β tubulins.</p>}}, author = {{Hamed, Abdelaaty and Ismail, Mohamed and El-Metwally, Mohammad M. and Frese, Marcel and Ibrahim, Tarek M.A. and El-Haddad, Atef F. and Sewald, Norbert and Shaaban, Mohamed}}, issn = {{0939-5075}}, keywords = {{biological properties; mol-docking; Penicillium sp.; polyketide-alkaloides; α; β tubulins}}, language = {{eng}}, month = {{05}}, number = {{5-6}}, pages = {{131--137}}, publisher = {{Verlag der Zeitschrift für Naturforschung}}, series = {{Zeitschrift fur Naturforschung - Section C Journal of Biosciences}}, title = {{Diverse polyketides and alkaloids from <i>Penicillium</i> sp. KHMM : structural elucidation, biological and molecular docking studies}}, url = {{http://dx.doi.org/10.1515/znc-2018-0145}}, doi = {{10.1515/znc-2018-0145}}, volume = {{74}}, year = {{2019}}, }