Cold exposure increases cyclic guanosine monophosphate in healthy women but not in women with Raynaud's phenomenon
(1995) In Journal of Internal Medicine 237(5). p.8-493- Abstract
OBJECTIVE: To investigate influence of whole-body cooling on cyclic GMP (cGMP) in women with Raynaud's phenomenon and in healthy women.
DESIGN: The study was performed as an open, parallel-group comparison between women with Raynaud's phenomenon and healthy women during the winter month of February.
SETTING: The municipality of Västerås (Sweden).
PARTICIPANTS: The Raynaud group comprised 24 female patients. The control group consisted of 21 healthy females.
MAIN OUTCOME MEASURE: The venous levels of cGMP were measured on three different occasions: just before and after 40 min of whole-body cooling and after 20 min rest at room temperature (21 degrees C).
RESULTS: Venous cGMP increased significantly in the control... (More)OBJECTIVE: To investigate influence of whole-body cooling on cyclic GMP (cGMP) in women with Raynaud's phenomenon and in healthy women.
(Less)
DESIGN: The study was performed as an open, parallel-group comparison between women with Raynaud's phenomenon and healthy women during the winter month of February.
SETTING: The municipality of Västerås (Sweden).
PARTICIPANTS: The Raynaud group comprised 24 female patients. The control group consisted of 21 healthy females.
MAIN OUTCOME MEASURE: The venous levels of cGMP were measured on three different occasions: just before and after 40 min of whole-body cooling and after 20 min rest at room temperature (21 degrees C).
RESULTS: Venous cGMP increased significantly in the control group after cold exposure (mean difference 0.43 pmol mL-1; 95% CI, 0.018-0.848; t = 2.18; df = 20; P = 0.02) and remained at a high level after 20 min rest (mean difference 0.58 pmol mL-1; 95% CI, 0.063-1.108; t = 2.34; df = 20; P = 0.015). In contrast, the levels of venous cGMP in the Raynaud group did not change significantly. The difference in increase between the two groups was significant (P < 0.02). The diastolic blood pressure in the Raynaud group increased after 40 min of whole-body cooling and was still significantly increased (P < 0.001) after 20 min rest at room temperature (21 degrees C).
CONCLUSION: These results indicate that women suffering from Raynaud's phenomenon lack the physiological response of cGMP to cold exposure, which may explain their increased vasospastic response.
- author
- Leppert, J ; Ringqvist, A LU ; Ahlner, J ; Myrdal, U ; Sørensen, S and Ringqvist, I
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Blood Pressure, Calcium/blood, Cold Temperature, Cyclic GMP/blood, Female, Heart Rate, Humans, Magnesium/blood, Middle Aged, Raynaud Disease/blood
- in
- Journal of Internal Medicine
- volume
- 237
- issue
- 5
- pages
- 8 - 493
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:7738490
- scopus:0029062384
- ISSN
- 0954-6820
- DOI
- 10.1111/j.1365-2796.1995.tb00875.x
- language
- English
- LU publication?
- no
- id
- a6886f44-20ed-4bf2-9bc0-547603af0cb0
- date added to LUP
- 2022-05-09 14:32:18
- date last changed
- 2024-01-03 10:25:04
@article{a6886f44-20ed-4bf2-9bc0-547603af0cb0,
abstract = {{<p>OBJECTIVE: To investigate influence of whole-body cooling on cyclic GMP (cGMP) in women with Raynaud's phenomenon and in healthy women.<br/>DESIGN: The study was performed as an open, parallel-group comparison between women with Raynaud's phenomenon and healthy women during the winter month of February.<br/>SETTING: The municipality of Västerås (Sweden).<br/>PARTICIPANTS: The Raynaud group comprised 24 female patients. The control group consisted of 21 healthy females.<br/>MAIN OUTCOME MEASURE: The venous levels of cGMP were measured on three different occasions: just before and after 40 min of whole-body cooling and after 20 min rest at room temperature (21 degrees C).<br/>RESULTS: Venous cGMP increased significantly in the control group after cold exposure (mean difference 0.43 pmol mL-1; 95% CI, 0.018-0.848; t = 2.18; df = 20; P = 0.02) and remained at a high level after 20 min rest (mean difference 0.58 pmol mL-1; 95% CI, 0.063-1.108; t = 2.34; df = 20; P = 0.015). In contrast, the levels of venous cGMP in the Raynaud group did not change significantly. The difference in increase between the two groups was significant (P < 0.02). The diastolic blood pressure in the Raynaud group increased after 40 min of whole-body cooling and was still significantly increased (P < 0.001) after 20 min rest at room temperature (21 degrees C).<br/>CONCLUSION: These results indicate that women suffering from Raynaud's phenomenon lack the physiological response of cGMP to cold exposure, which may explain their increased vasospastic response.</p>}},
author = {{Leppert, J and Ringqvist, A and Ahlner, J and Myrdal, U and Sørensen, S and Ringqvist, I}},
issn = {{0954-6820}},
keywords = {{Adult; Blood Pressure; Calcium/blood; Cold Temperature; Cyclic GMP/blood; Female; Heart Rate; Humans; Magnesium/blood; Middle Aged; Raynaud Disease/blood}},
language = {{eng}},
number = {{5}},
pages = {{8--493}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Cold exposure increases cyclic guanosine monophosphate in healthy women but not in women with Raynaud's phenomenon}},
url = {{http://dx.doi.org/10.1111/j.1365-2796.1995.tb00875.x}},
doi = {{10.1111/j.1365-2796.1995.tb00875.x}},
volume = {{237}},
year = {{1995}},
}