Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity
(2007) In Nano Letters 7(4). p.914-920- Abstract
- Nanoparticles in biological fluids almost invariably become coated with proteins that may confer nanomedical and nanotoxicological effects. Understanding these effects requires quantitative measurements using simple systems. Adsorption of HSA to copolymer nanoparticles of varying hydrophobicity and curvature was studied using ITC, yielding stoichiometry, affinity, and enthalpy changes upon binding. The hydrophobicity was controlled via the co-monomer ratio, N-iso-propylacrylamide/N-tert-butylacrylamide. The most hydrophobic particles become fully covered with a single layer of protein, except at high curvature.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/666370
- author
- Lindman, Stina LU ; Lynch, Iseult LU ; Thulin, Eva LU ; Nilsson, Hanna LU ; Dawson, Kenneth and Linse, Sara LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nano Letters
- volume
- 7
- issue
- 4
- pages
- 914 - 920
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000245600500012
- scopus:34248155667
- ISSN
- 1530-6992
- DOI
- 10.1021/nl062743+
- language
- English
- LU publication?
- yes
- id
- a6a03451-1912-43e8-98a7-9c0561bad813 (old id 666370)
- date added to LUP
- 2016-04-01 15:27:02
- date last changed
- 2022-04-22 07:42:14
@article{a6a03451-1912-43e8-98a7-9c0561bad813, abstract = {{Nanoparticles in biological fluids almost invariably become coated with proteins that may confer nanomedical and nanotoxicological effects. Understanding these effects requires quantitative measurements using simple systems. Adsorption of HSA to copolymer nanoparticles of varying hydrophobicity and curvature was studied using ITC, yielding stoichiometry, affinity, and enthalpy changes upon binding. The hydrophobicity was controlled via the co-monomer ratio, N-iso-propylacrylamide/N-tert-butylacrylamide. The most hydrophobic particles become fully covered with a single layer of protein, except at high curvature.}}, author = {{Lindman, Stina and Lynch, Iseult and Thulin, Eva and Nilsson, Hanna and Dawson, Kenneth and Linse, Sara}}, issn = {{1530-6992}}, language = {{eng}}, number = {{4}}, pages = {{914--920}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Nano Letters}}, title = {{Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity}}, url = {{http://dx.doi.org/10.1021/nl062743+}}, doi = {{10.1021/nl062743+}}, volume = {{7}}, year = {{2007}}, }