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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Steinthorsdottir, Valgerdur ; Fadista, Joao LU and Morgan, Linda (2020) In Nature Communications 11(1).
Abstract
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that... (More)
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia. © 2020, The Author(s). (Less)
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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood, body mass, genome, meta-analysis, public health, risk assessment
in
Nature Communications
volume
11
issue
1
article number
5976
publisher
Nature Publishing Group
external identifiers
  • scopus:85096579509
  • pmid:33239696
ISSN
2041-1723
DOI
10.1038/s41467-020-19733-6
language
English
LU publication?
yes
id
a6b6540a-6095-432b-9f52-8ae1ba020ef3
date added to LUP
2020-12-03 13:21:17
date last changed
2024-05-01 21:09:57
@article{a6b6540a-6095-432b-9f52-8ae1ba020ef3,
  abstract     = {{Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia. © 2020, The Author(s).}},
  author       = {{Steinthorsdottir, Valgerdur and Fadista, Joao and Morgan, Linda}},
  issn         = {{2041-1723}},
  keywords     = {{blood; body mass; genome; meta-analysis; public health; risk assessment}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women}},
  url          = {{http://dx.doi.org/10.1038/s41467-020-19733-6}},
  doi          = {{10.1038/s41467-020-19733-6}},
  volume       = {{11}},
  year         = {{2020}},
}