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Alkanolamide biosurfactants: techno-economic evaluation of enzymatic versus chemical production

Adlercreutz, Dietlind LU ; Tufvesson, Pär LU ; Karlsson, Annika J. and Hatti-Kaul, Rajni LU (2010) In Industrial Biotechnology 6(4). p.204-211
Abstract
Alkanolamides are biosurfactants used in a range of products for cleaning and other applications. Recently, an environmentally benign and volume-efficient biocatalytic process for production of high-quality alkanolamides was developed in our laboratory. In the current investigation, this process is evaluated in terms of technical and economic feasibility on a multi-tonne scale using commercial process optimization software and compared with known chemical processes. Energy demands for the processes and in raw material production were also compared. A campaign for manufacturing 200 tonnes of alkanolamides was considered. When using a 20 m3 reactor and 5% (w/w) loading of an immobilized lipase (Novozym®435; Novozymes), 20 batches and a total... (More)
Alkanolamides are biosurfactants used in a range of products for cleaning and other applications. Recently, an environmentally benign and volume-efficient biocatalytic process for production of high-quality alkanolamides was developed in our laboratory. In the current investigation, this process is evaluated in terms of technical and economic feasibility on a multi-tonne scale using commercial process optimization software and compared with known chemical processes. Energy demands for the processes and in raw material production were also compared. A campaign for manufacturing 200 tonnes of alkanolamides was considered. When using a 20 m3 reactor and 5% (w/w) loading of an immobilized lipase (Novozym®435; Novozymes), 20 batches and a total process time of 101 hours are required for the whole campaign. The biocatalytic process was relatively more energy-efficient, but production costs were calculated to be about 1.4 times that of the corresponding conventional alkanolamide manufacturing process utilizing sodium methylate as a catalyst. The principal contributor to the extra costs is the cost of the immobilized enzyme. There is a great potential to decrease enzyme costs; industrialization may, however, depend on the possibility of obtaining a higher price for the biocatalytic product. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Industrial Biotechnology
volume
6
issue
4
pages
204 - 211
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:78650511575
ISSN
1550-9087
DOI
10.1089/ind.2010.6.204
language
English
LU publication?
yes
id
a6b7849d-825e-4be2-a840-0d3f45f194d4
date added to LUP
2019-06-29 19:59:57
date last changed
2020-09-23 07:48:36
@article{a6b7849d-825e-4be2-a840-0d3f45f194d4,
  abstract     = {Alkanolamides are biosurfactants used in a range of products for cleaning and other applications. Recently, an environmentally benign and volume-efficient biocatalytic process for production of high-quality alkanolamides was developed in our laboratory. In the current investigation, this process is evaluated in terms of technical and economic feasibility on a multi-tonne scale using commercial process optimization software and compared with known chemical processes. Energy demands for the processes and in raw material production were also compared. A campaign for manufacturing 200 tonnes of alkanolamides was considered. When using a 20 m3 reactor and 5% (w/w) loading of an immobilized lipase (Novozym®435; Novozymes), 20 batches and a total process time of 101 hours are required for the whole campaign. The biocatalytic process was relatively more energy-efficient, but production costs were calculated to be about 1.4 times that of the corresponding conventional alkanolamide manufacturing process utilizing sodium methylate as a catalyst. The principal contributor to the extra costs is the cost of the immobilized enzyme. There is a great potential to decrease enzyme costs; industrialization may, however, depend on the possibility of obtaining a higher price for the biocatalytic product.},
  author       = {Adlercreutz, Dietlind and Tufvesson, Pär and Karlsson, Annika J. and Hatti-Kaul, Rajni},
  issn         = {1550-9087},
  language     = {eng},
  number       = {4},
  pages        = {204--211},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Industrial Biotechnology},
  title        = {Alkanolamide biosurfactants: techno-economic evaluation of enzymatic versus chemical production},
  url          = {http://dx.doi.org/10.1089/ind.2010.6.204},
  doi          = {10.1089/ind.2010.6.204},
  volume       = {6},
  year         = {2010},
}