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The apparent plasticizing effect of polyethylene glycol (PEG) on the crystallinity of spray dried lactose/PEG composites

Mosén, Kristina LU ; Backstrom, Kjell; Thalberg, Kyrre; Schaefer, Torben; Axelsson, Anders LU and Kristensen, Hennina G. (2006) In European Journal of Pharmaceutics and Biopharmaceutics 64(2). p.206-211
Abstract
Aqueous solutions of lactose and polyethylene glycol (PEG) were spray dried in a Buchi Model 191 spray dryer with the aim to investigate the effect of PEG on the crystallinity of the composite. A PEG concentration of 10.7% by weight of solids was studied for PEG 200, 600, 1500, 4000 and 8000. For PEG 200 and 4000 additional concentrations from 1.5-19.3% to 1.5-32.4%, respectively, were investigated. The spray dried composites were analysed with X-ray powder diffraction and modulating differential scanning calorimetry. The crystallinity of lactose in the composites varied from 0% to 60%, dependent on the molecular weight and concentration of PEG. Apparently, lactose crystallinity is promoted by low molecular weight and high concentration of... (More)
Aqueous solutions of lactose and polyethylene glycol (PEG) were spray dried in a Buchi Model 191 spray dryer with the aim to investigate the effect of PEG on the crystallinity of the composite. A PEG concentration of 10.7% by weight of solids was studied for PEG 200, 600, 1500, 4000 and 8000. For PEG 200 and 4000 additional concentrations from 1.5-19.3% to 1.5-32.4%, respectively, were investigated. The spray dried composites were analysed with X-ray powder diffraction and modulating differential scanning calorimetry. The crystallinity of lactose in the composites varied from 0% to 60%, dependent on the molecular weight and concentration of PEG. Apparently, lactose crystallinity is promoted by low molecular weight and high concentration of the PEG. PEG did not affect the lactose glass transition temperature. It is suggested that lactose and PEG are solidified separately during spray drying and that partial crystallization of lactose is associated with effects of PEG on the rate of drying. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
temperature, glass transition, lactose, spray drying, polyethylene glycol, crystallinity
in
European Journal of Pharmaceutics and Biopharmaceutics
volume
64
issue
2
pages
206 - 211
publisher
Elsevier
external identifiers
  • wos:000240726800012
  • scopus:33748176960
ISSN
0939-6411
DOI
10.1016/j.ejpb.2006.05.015
language
English
LU publication?
yes
id
a6baf963-9b1a-43da-b303-82a101abc052 (old id 392752)
date added to LUP
2007-10-10 22:34:22
date last changed
2019-10-23 02:07:57
@article{a6baf963-9b1a-43da-b303-82a101abc052,
  abstract     = {Aqueous solutions of lactose and polyethylene glycol (PEG) were spray dried in a Buchi Model 191 spray dryer with the aim to investigate the effect of PEG on the crystallinity of the composite. A PEG concentration of 10.7% by weight of solids was studied for PEG 200, 600, 1500, 4000 and 8000. For PEG 200 and 4000 additional concentrations from 1.5-19.3% to 1.5-32.4%, respectively, were investigated. The spray dried composites were analysed with X-ray powder diffraction and modulating differential scanning calorimetry. The crystallinity of lactose in the composites varied from 0% to 60%, dependent on the molecular weight and concentration of PEG. Apparently, lactose crystallinity is promoted by low molecular weight and high concentration of the PEG. PEG did not affect the lactose glass transition temperature. It is suggested that lactose and PEG are solidified separately during spray drying and that partial crystallization of lactose is associated with effects of PEG on the rate of drying.},
  author       = {Mosén, Kristina and Backstrom, Kjell and Thalberg, Kyrre and Schaefer, Torben and Axelsson, Anders and Kristensen, Hennina G.},
  issn         = {0939-6411},
  keyword      = {temperature,glass transition,lactose,spray drying,polyethylene glycol,crystallinity},
  language     = {eng},
  number       = {2},
  pages        = {206--211},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmaceutics and Biopharmaceutics},
  title        = {The apparent plasticizing effect of polyethylene glycol (PEG) on the crystallinity of spray dried lactose/PEG composites},
  url          = {http://dx.doi.org/10.1016/j.ejpb.2006.05.015},
  volume       = {64},
  year         = {2006},
}