Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study
(2011) In Calcified Tissue International 88(6). p.503-510- Abstract
- The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study (EMAS). Subjects were invited by letter to complete a postal questionnaire and to attend for an interviewer-assisted questionnaire, quantitative ultrasound (QUS) of the calcaneus, and a fasting blood sample from which serum levels of IGFBP-1, IGFBP-3, IGF-I, estradiol (E-2), and SHBG were assayed. The questionnaires included the Physical Activity Scale for the Elderly (PASE) and questions about smoking and alcohol consumption.... (More)
- The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study (EMAS). Subjects were invited by letter to complete a postal questionnaire and to attend for an interviewer-assisted questionnaire, quantitative ultrasound (QUS) of the calcaneus, and a fasting blood sample from which serum levels of IGFBP-1, IGFBP-3, IGF-I, estradiol (E-2), and SHBG were assayed. The questionnaires included the Physical Activity Scale for the Elderly (PASE) and questions about smoking and alcohol consumption. Estimated bone mineral density (eBMD) was derived as a function of the QUS parameters speed of sound and broadband ultrasound attenuation. Height and weight were measured in all subjects. 3057 men, mean age 59.7 years (standard deviation 11.0) were included in the analysis. After adjusting for age, center, and BMI, higher levels of IGFBP-1 were associated with lower eBMD. Higher levels of both IGFBP-3 and IGF-I were associated with higher eBMD. After further adjustment for PASE score, current smoking, alcohol consumption, free E-2, and SHBG, IGFBP-3 and IGF-I, though not IGFBP-1, remained significantly associated with eBMD. IGFBP-1 was associated with bone health, though the effect could be explained by other factors. IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men. (Less)
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- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Insulin-like growth factor binding protein 1, Insulin-like growth, factor binding protein 3, Calcaneus quantitative ultrasound, Population-based, Men
- in
- Calcified Tissue International
- volume
- 88
- issue
- 6
- pages
- 503 - 510
- publisher
- Springer
- external identifiers
-
- wos:000290537300007
- scopus:84943015768
- ISSN
- 1432-0827
- DOI
- 10.1007/s00223-011-9484-2
- language
- English
- LU publication?
- yes
- id
- a6c5d63a-7239-4168-9dbd-586fd7f4773d (old id 1986997)
- date added to LUP
- 2016-04-01 14:07:39
- date last changed
- 2022-01-27 22:50:23
@article{a6c5d63a-7239-4168-9dbd-586fd7f4773d,
abstract = {{The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study (EMAS). Subjects were invited by letter to complete a postal questionnaire and to attend for an interviewer-assisted questionnaire, quantitative ultrasound (QUS) of the calcaneus, and a fasting blood sample from which serum levels of IGFBP-1, IGFBP-3, IGF-I, estradiol (E-2), and SHBG were assayed. The questionnaires included the Physical Activity Scale for the Elderly (PASE) and questions about smoking and alcohol consumption. Estimated bone mineral density (eBMD) was derived as a function of the QUS parameters speed of sound and broadband ultrasound attenuation. Height and weight were measured in all subjects. 3057 men, mean age 59.7 years (standard deviation 11.0) were included in the analysis. After adjusting for age, center, and BMI, higher levels of IGFBP-1 were associated with lower eBMD. Higher levels of both IGFBP-3 and IGF-I were associated with higher eBMD. After further adjustment for PASE score, current smoking, alcohol consumption, free E-2, and SHBG, IGFBP-3 and IGF-I, though not IGFBP-1, remained significantly associated with eBMD. IGFBP-1 was associated with bone health, though the effect could be explained by other factors. IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men.}},
author = {{Pye, Stephen R. and Almusalam, Bader and Boonen, Steven and Vanderschueren, Dirk and Borghs, Herman and Gielen, Evelien and Adams, Judith E. and Ward, Kate A. and Bartfai, Gyorgy and Casanueva, Felipe F. and Finn, Joseph D. and Forti, Gianni and Giwercman, Aleksander and Han, Thang S. and Huhtaniemi, Ilpo T. and Kula, Krzysztof and Labrie, Fernand and Lean, Michael E. J. and Pendleton, Neil and Punab, Margus and Silman, Alan J. and Wu, Frederick C. W. and O'Neill, Terence W.}},
issn = {{1432-0827}},
keywords = {{Insulin-like growth factor binding protein 1; Insulin-like growth; factor binding protein 3; Calcaneus quantitative ultrasound; Population-based; Men}},
language = {{eng}},
number = {{6}},
pages = {{503--510}},
publisher = {{Springer}},
series = {{Calcified Tissue International}},
title = {{Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study}},
url = {{http://dx.doi.org/10.1007/s00223-011-9484-2}},
doi = {{10.1007/s00223-011-9484-2}},
volume = {{88}},
year = {{2011}},
}