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Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI-RS 2019

Speich, John E. ; Tarcan, Tufan ; Hashitani, Hikaru ; Vahabi, Bahareh ; McCloskey, Karen D. ; Andersson, Karl Erik LU orcid ; Wein, Alan J. and Birder, Lori A. (2020) In Neurourology and Urodynamics 39(S3). p.16-22
Abstract

Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence—Research Society (ICI-RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared with ischemia of other organs, and the ongoing development of pelvic ischemia animal models is discussed. In... (More)

Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence—Research Society (ICI-RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared with ischemia of other organs, and the ongoing development of pelvic ischemia animal models is discussed. In addition, the distribution of blood within the bladder during filling and voiding and the challenges of quantification of blood flow in vivo are described. Furthermore, oxidative stress, including potential biomarkers and treatments, and challenges regarding antioxidant therapy for the treatment of LUTD are discussed. Finally, seven critical research questions and proposed studies to answer those questions were identified as priorities that would lead to major advances in the understanding and treatment of lower urinary tract symptoms (LUTS)/LUTD associated with pelvic ischemia and oxidative stress.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lower urinary tract symptoms, oxidative stress, pelvic ischemia
in
Neurourology and Urodynamics
volume
39
issue
S3
pages
16 - 22
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85079706920
  • pmid:32056281
ISSN
0733-2467
DOI
10.1002/nau.24313
language
English
LU publication?
yes
id
a72dd74b-40b3-48cd-ab26-d6e3f577ce80
date added to LUP
2020-03-04 12:01:41
date last changed
2024-06-12 09:53:07
@article{a72dd74b-40b3-48cd-ab26-d6e3f577ce80,
  abstract     = {{<p>Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence—Research Society (ICI-RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared with ischemia of other organs, and the ongoing development of pelvic ischemia animal models is discussed. In addition, the distribution of blood within the bladder during filling and voiding and the challenges of quantification of blood flow in vivo are described. Furthermore, oxidative stress, including potential biomarkers and treatments, and challenges regarding antioxidant therapy for the treatment of LUTD are discussed. Finally, seven critical research questions and proposed studies to answer those questions were identified as priorities that would lead to major advances in the understanding and treatment of lower urinary tract symptoms (LUTS)/LUTD associated with pelvic ischemia and oxidative stress.</p>}},
  author       = {{Speich, John E. and Tarcan, Tufan and Hashitani, Hikaru and Vahabi, Bahareh and McCloskey, Karen D. and Andersson, Karl Erik and Wein, Alan J. and Birder, Lori A.}},
  issn         = {{0733-2467}},
  keywords     = {{lower urinary tract symptoms; oxidative stress; pelvic ischemia}},
  language     = {{eng}},
  number       = {{S3}},
  pages        = {{16--22}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Neurourology and Urodynamics}},
  title        = {{Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI-RS 2019}},
  url          = {{http://dx.doi.org/10.1002/nau.24313}},
  doi          = {{10.1002/nau.24313}},
  volume       = {{39}},
  year         = {{2020}},
}