Linking structural and functional changes during aging using multilayer brain network analysis
(2024) In Communications Biology 7(1).- Abstract
Brain structure and function are intimately linked, however this association remains poorly understood and the complexity of this relationship has remained understudied. Healthy aging is characterised by heterogenous levels of structural integrity changes that influence functional network dynamics. Here, we use the multilayer brain network analysis on structural (diffusion weighted imaging) and functional (magnetoencephalography) data from the Cam-CAN database. We found that the level of similarity of connectivity patterns between brain structure and function in the parietal and temporal regions (alpha frequency band) is associated with cognitive performance in healthy older individuals. These results highlight the impact of structural... (More)
Brain structure and function are intimately linked, however this association remains poorly understood and the complexity of this relationship has remained understudied. Healthy aging is characterised by heterogenous levels of structural integrity changes that influence functional network dynamics. Here, we use the multilayer brain network analysis on structural (diffusion weighted imaging) and functional (magnetoencephalography) data from the Cam-CAN database. We found that the level of similarity of connectivity patterns between brain structure and function in the parietal and temporal regions (alpha frequency band) is associated with cognitive performance in healthy older individuals. These results highlight the impact of structural connectivity changes on the reorganisation of functional connectivity associated with the preservation of cognitive function, and provide a mechanistic understanding of the concepts of brain maintenance and compensation with aging. Investigation of the link between structure and function could thus represent a new marker of individual variability, and of pathological changes.
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- author
- Jauny, Gwendolyn ; Mijalkov, Mite ; Canal-Garcia, Anna ; Volpe, Giovanni ; Pereira, Joana LU ; Eustache, Francis and Hinault, Thomas
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Communications Biology
- volume
- 7
- issue
- 1
- article number
- 239
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:38418523
- scopus:85186254055
- ISSN
- 2399-3642
- DOI
- 10.1038/s42003-024-05927-x
- language
- English
- LU publication?
- yes
- id
- a7542150-5e2d-4ffd-afc9-98733e39ab5f
- date added to LUP
- 2024-03-14 10:35:16
- date last changed
- 2024-04-25 07:11:08
@article{a7542150-5e2d-4ffd-afc9-98733e39ab5f,
abstract = {{<p>Brain structure and function are intimately linked, however this association remains poorly understood and the complexity of this relationship has remained understudied. Healthy aging is characterised by heterogenous levels of structural integrity changes that influence functional network dynamics. Here, we use the multilayer brain network analysis on structural (diffusion weighted imaging) and functional (magnetoencephalography) data from the Cam-CAN database. We found that the level of similarity of connectivity patterns between brain structure and function in the parietal and temporal regions (alpha frequency band) is associated with cognitive performance in healthy older individuals. These results highlight the impact of structural connectivity changes on the reorganisation of functional connectivity associated with the preservation of cognitive function, and provide a mechanistic understanding of the concepts of brain maintenance and compensation with aging. Investigation of the link between structure and function could thus represent a new marker of individual variability, and of pathological changes.</p>}},
author = {{Jauny, Gwendolyn and Mijalkov, Mite and Canal-Garcia, Anna and Volpe, Giovanni and Pereira, Joana and Eustache, Francis and Hinault, Thomas}},
issn = {{2399-3642}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Communications Biology}},
title = {{Linking structural and functional changes during aging using multilayer brain network analysis}},
url = {{http://dx.doi.org/10.1038/s42003-024-05927-x}},
doi = {{10.1038/s42003-024-05927-x}},
volume = {{7}},
year = {{2024}},
}