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Membrane Processes for the Production of Bulk Fermentation Products

Lipnizki, Frank LU (2010) In Membrane Technology p.121-153
Abstract

The ultrafiltration (UF) with diafiltration is the state-of-the-art process in the bulk pharmaceutical industry to separate solutions containing high and low molecular weight solutes. By applying UF with diafiltration, a feed stream can be separated into a concentrate with a high concentration of high molecular weight solutes and a permeate, which is nearly 100% free of high molecular weight solutes. The UF with diafiltration process commonly consists of three stages that include a preconcentration stage achieving similar concentrations of low molecular weight components in retentate and permeate, a diafiltration stage to purify retentate by addition of a diafiltration liquid, and a final concentration stage to maximize the... (More)

The ultrafiltration (UF) with diafiltration is the state-of-the-art process in the bulk pharmaceutical industry to separate solutions containing high and low molecular weight solutes. By applying UF with diafiltration, a feed stream can be separated into a concentrate with a high concentration of high molecular weight solutes and a permeate, which is nearly 100% free of high molecular weight solutes. The UF with diafiltration process commonly consists of three stages that include a preconcentration stage achieving similar concentrations of low molecular weight components in retentate and permeate, a diafiltration stage to purify retentate by addition of a diafiltration liquid, and a final concentration stage to maximize the concentration of high molecular weight solutes in retentate. UF combined with diafiltration is used after the fermentation to separate the citric acid from the biomass. The UF permeate can then be further purified by using reverse osmosis (RO)/nanofiltration (NF) to remove any remaining impurities such as biomass, salts, and sucrose and thus minimizing the posttreatment. The purified citric acid is then mixed with calcium carbonate resulting in calcium citrate containing approximately 75% of citric acid. Electrodialysis (ED) is used as a recovery method for the citric acid to replace the lime/sulfuric acid precipitation and thus avoid the production of calcium sulfate as a by-product from the citric acid production.

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Please use this url to cite or link to this publication:
author
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
in
Membrane Technology
pages
33 pages
publisher
IFAC & Elsevier Ltd.
external identifiers
  • scopus:84882477464
ISBN
978-1-85617-632-3
DOI
10.1016/B978-1-85617-632-3.00007-0
language
English
LU publication?
no
id
a7732ba0-2304-401e-849e-a5393dd94ac5
date added to LUP
2017-01-23 13:46:16
date last changed
2018-05-29 11:41:01
@inbook{a7732ba0-2304-401e-849e-a5393dd94ac5,
  abstract     = {<p>The ultrafiltration (UF) with diafiltration is the state-of-the-art process in the bulk pharmaceutical industry to separate solutions containing high and low molecular weight solutes. By applying UF with diafiltration, a feed stream can be separated into a concentrate with a high concentration of high molecular weight solutes and a permeate, which is nearly 100% free of high molecular weight solutes. The UF with diafiltration process commonly consists of three stages that include a preconcentration stage achieving similar concentrations of low molecular weight components in retentate and permeate, a diafiltration stage to purify retentate by addition of a diafiltration liquid, and a final concentration stage to maximize the concentration of high molecular weight solutes in retentate. UF combined with diafiltration is used after the fermentation to separate the citric acid from the biomass. The UF permeate can then be further purified by using reverse osmosis (RO)/nanofiltration (NF) to remove any remaining impurities such as biomass, salts, and sucrose and thus minimizing the posttreatment. The purified citric acid is then mixed with calcium carbonate resulting in calcium citrate containing approximately 75% of citric acid. Electrodialysis (ED) is used as a recovery method for the citric acid to replace the lime/sulfuric acid precipitation and thus avoid the production of calcium sulfate as a by-product from the citric acid production.</p>},
  author       = {Lipnizki, Frank},
  isbn         = {978-1-85617-632-3},
  language     = {eng},
  pages        = {121--153},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {Membrane Technology},
  title        = {Membrane Processes for the Production of Bulk Fermentation Products},
  url          = {http://dx.doi.org/10.1016/B978-1-85617-632-3.00007-0},
  year         = {2010},
}