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Intracerebral microdialysis of glutamate and aspartate in two vascular territories after aneurysmal subarachnoid hemorrhage

Säveland, Hans LU ; Nilsson, Ola G. LU ; Boris-Möller, Fredrik LU ; Wieloch, Tadeuz LU and Brandt, Lennart LU (1996) In Neurosurgery 38(1). p.12-20
Abstract

CEREBRAL ISCHEMIA ASSOCIATED with subarachnoid hemorrhage may have severe consequences for neuronal functioning. The excitatory amino acid neurotransmitters glutamate and aspartate have been shown to he of particular importance for ischemia and ischemic neuronal damage. For seven patients who underwent early surgery for ruptured intracranial aneurysms, intracerebral microdialysis of glutamate and aspartate was performed to monitor local metabolic changes in the medial temporal (all seven patients) and subfrontal cortex (Patients 4 through 7). Samples were collected every 30 or 60 minutes, using an autosampler. The results show that extracellular glutamate and aspartate concentrations can rise to very high levels after surgery for... (More)

CEREBRAL ISCHEMIA ASSOCIATED with subarachnoid hemorrhage may have severe consequences for neuronal functioning. The excitatory amino acid neurotransmitters glutamate and aspartate have been shown to he of particular importance for ischemia and ischemic neuronal damage. For seven patients who underwent early surgery for ruptured intracranial aneurysms, intracerebral microdialysis of glutamate and aspartate was performed to monitor local metabolic changes in the medial temporal (all seven patients) and subfrontal cortex (Patients 4 through 7). Samples were collected every 30 or 60 minutes, using an autosampler. The results show that extracellular glutamate and aspartate concentrations can rise to very high levels after surgery for subarachnoid hemorrhage and aneurysm. These increased levels of excitatory amino acids correlated well with the clinical course and neurological symptoms of the patients. Simultaneous sampling from two vascular territories (middle cerebral artery and anterior cerebral artery) also showed that a rise in extracellular glutamate and aspartate in one territory is not necessarily parallel with a rise in the other. The application of the microdialysis technique with an on-line assay system might be of value in the future for continuous monitoring of ischemic events to optimize treatment with, for example, blockers of glutamatergic neurotransmission.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aneurysmal subarachnoid hemorrhage, Aspartate, Glutamate, Intracerebral microdialysis, Ischemia
in
Neurosurgery
volume
38
issue
1
pages
9 pages
publisher
Oxford University Press
external identifiers
  • pmid:8747946
  • scopus:0030058656
ISSN
0148-396X
DOI
10.1097/00006123-199601000-00004
language
English
LU publication?
yes
id
a7b64aaf-53d0-4c42-9142-49478eb32245
date added to LUP
2019-06-13 16:04:17
date last changed
2023-09-09 06:01:37
@article{a7b64aaf-53d0-4c42-9142-49478eb32245,
  abstract     = {{<p>CEREBRAL ISCHEMIA ASSOCIATED with subarachnoid hemorrhage may have severe consequences for neuronal functioning. The excitatory amino acid neurotransmitters glutamate and aspartate have been shown to he of particular importance for ischemia and ischemic neuronal damage. For seven patients who underwent early surgery for ruptured intracranial aneurysms, intracerebral microdialysis of glutamate and aspartate was performed to monitor local metabolic changes in the medial temporal (all seven patients) and subfrontal cortex (Patients 4 through 7). Samples were collected every 30 or 60 minutes, using an autosampler. The results show that extracellular glutamate and aspartate concentrations can rise to very high levels after surgery for subarachnoid hemorrhage and aneurysm. These increased levels of excitatory amino acids correlated well with the clinical course and neurological symptoms of the patients. Simultaneous sampling from two vascular territories (middle cerebral artery and anterior cerebral artery) also showed that a rise in extracellular glutamate and aspartate in one territory is not necessarily parallel with a rise in the other. The application of the microdialysis technique with an on-line assay system might be of value in the future for continuous monitoring of ischemic events to optimize treatment with, for example, blockers of glutamatergic neurotransmission.</p>}},
  author       = {{Säveland, Hans and Nilsson, Ola G. and Boris-Möller, Fredrik and Wieloch, Tadeuz and Brandt, Lennart}},
  issn         = {{0148-396X}},
  keywords     = {{Aneurysmal subarachnoid hemorrhage; Aspartate; Glutamate; Intracerebral microdialysis; Ischemia}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{12--20}},
  publisher    = {{Oxford University Press}},
  series       = {{Neurosurgery}},
  title        = {{Intracerebral microdialysis of glutamate and aspartate in two vascular territories after aneurysmal subarachnoid hemorrhage}},
  url          = {{http://dx.doi.org/10.1097/00006123-199601000-00004}},
  doi          = {{10.1097/00006123-199601000-00004}},
  volume       = {{38}},
  year         = {{1996}},
}