Heparan sulfate proteoglycan as a plasma membrane carrier
(2003) In Trends in Biochemical Sciences 28(3). p.145-151- Abstract
- The plasma membrane defines the border of living cells and provides a barrier to extracellular components. Advances in molecular biology have resulted in the development of novel therapeutic strategies (e.g. gene therapy and cellular protein delivery) which rely on the entry of charged macromolecules into the intracellular compartment. Recent reports demonstrate an intriguing role for heparan sulfate proteoglycans in cellular internalization of viruses, basic peptides and polycation-nucleic-acid complexes and the possibility that they have important implications for gene transfer and protein delivery to mammalian cells. This review focuses on heparan sulfate proteoglycan as a plasma membrane carrier.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1127610
- author
- Belting, Mattias LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Biochemical Sciences
- volume
- 28
- issue
- 3
- pages
- 145 - 151
- publisher
- Elsevier
- external identifiers
-
- pmid:12633994
- scopus:0037333830
- ISSN
- 0167-7640
- DOI
- 10.1016/S0968-0004(03)00031-8
- language
- English
- LU publication?
- yes
- id
- a7bfd267-cd28-4eec-8bd8-e1f31b38f800 (old id 1127610)
- date added to LUP
- 2016-04-01 12:10:07
- date last changed
- 2022-03-28 21:13:00
@article{a7bfd267-cd28-4eec-8bd8-e1f31b38f800, abstract = {{The plasma membrane defines the border of living cells and provides a barrier to extracellular components. Advances in molecular biology have resulted in the development of novel therapeutic strategies (e.g. gene therapy and cellular protein delivery) which rely on the entry of charged macromolecules into the intracellular compartment. Recent reports demonstrate an intriguing role for heparan sulfate proteoglycans in cellular internalization of viruses, basic peptides and polycation-nucleic-acid complexes and the possibility that they have important implications for gene transfer and protein delivery to mammalian cells. This review focuses on heparan sulfate proteoglycan as a plasma membrane carrier.}}, author = {{Belting, Mattias}}, issn = {{0167-7640}}, language = {{eng}}, number = {{3}}, pages = {{145--151}}, publisher = {{Elsevier}}, series = {{Trends in Biochemical Sciences}}, title = {{Heparan sulfate proteoglycan as a plasma membrane carrier}}, url = {{http://dx.doi.org/10.1016/S0968-0004(03)00031-8}}, doi = {{10.1016/S0968-0004(03)00031-8}}, volume = {{28}}, year = {{2003}}, }