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Fatty acid composition of milk from mothers giving birth at extremely low gestation in Sweden

Sjobom, Ulrika ; Cismaan, Osman ; Hansen-Pupp, Ingrid LU orcid ; Wackernagel, Dirk ; Savman, Karin ; Hellstrom, Ann LU and Nilsson, Anders K. LU (2022) In Experimental Results 3.
Abstract

Preterm infants show postnatal deficits of long-chain polyunsaturated fatty acids (LCPUFAs) which are essential for adequate growth and neurodevelopment. Human milk is a primary source of fatty acids (FAs) for the preterm infant, and therefore, knowledge about milk FA levels is required to design appropriate supplementation strategies. Here, we expanded on our previous study (Nilsson et al., 2018, Acta Paediatrica, 107, 1020-1027) determining FA composition in milk obtained from mothers of extremely low gestational age (<28 weeks) infants on three occasions during lactation. There was a clear difference in FA composition in milk collected at Day 7 and milk collected at postmenstrual weeks (PMW) 32 or PMW 40. Notably, the proportion... (More)

Preterm infants show postnatal deficits of long-chain polyunsaturated fatty acids (LCPUFAs) which are essential for adequate growth and neurodevelopment. Human milk is a primary source of fatty acids (FAs) for the preterm infant, and therefore, knowledge about milk FA levels is required to design appropriate supplementation strategies. Here, we expanded on our previous study (Nilsson et al., 2018, Acta Paediatrica, 107, 1020-1027) determining FA composition in milk obtained from mothers of extremely low gestational age (<28 weeks) infants on three occasions during lactation. There was a clear difference in FA composition in milk collected at Day 7 and milk collected at postmenstrual weeks (PMW) 32 or PMW 40. Notably, the proportion of LCPUFAs was low and declined significantly during milk maturation. These results strengthen previous data that the content of FAs required by the preterm infant is not supplied in sufficient amounts when the mother's own milk is the sole source of these essential nutrients.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
docosahexaenoic acid, expressed milk, human milk, long-chain polyunsaturated fatty acids, preterm infant
in
Experimental Results
volume
3
article number
e9
publisher
Cambridge University Press
external identifiers
  • scopus:85136976418
ISSN
2516-712X
DOI
10.1017/exp.2022.4
language
English
LU publication?
yes
id
a7e09c6c-b00a-4f26-98cc-e93dea5ee114
date added to LUP
2022-11-08 13:07:21
date last changed
2023-10-09 02:29:13
@article{a7e09c6c-b00a-4f26-98cc-e93dea5ee114,
  abstract     = {{<p>Preterm infants show postnatal deficits of long-chain polyunsaturated fatty acids (LCPUFAs) which are essential for adequate growth and neurodevelopment. Human milk is a primary source of fatty acids (FAs) for the preterm infant, and therefore, knowledge about milk FA levels is required to design appropriate supplementation strategies. Here, we expanded on our previous study (Nilsson et al., 2018, Acta Paediatrica, 107, 1020-1027) determining FA composition in milk obtained from mothers of extremely low gestational age (&lt;28 weeks) infants on three occasions during lactation. There was a clear difference in FA composition in milk collected at Day 7 and milk collected at postmenstrual weeks (PMW) 32 or PMW 40. Notably, the proportion of LCPUFAs was low and declined significantly during milk maturation. These results strengthen previous data that the content of FAs required by the preterm infant is not supplied in sufficient amounts when the mother's own milk is the sole source of these essential nutrients.</p>}},
  author       = {{Sjobom, Ulrika and Cismaan, Osman and Hansen-Pupp, Ingrid and Wackernagel, Dirk and Savman, Karin and Hellstrom, Ann and Nilsson, Anders K.}},
  issn         = {{2516-712X}},
  keywords     = {{docosahexaenoic acid; expressed milk; human milk; long-chain polyunsaturated fatty acids; preterm infant}},
  language     = {{eng}},
  publisher    = {{Cambridge University Press}},
  series       = {{Experimental Results}},
  title        = {{Fatty acid composition of milk from mothers giving birth at extremely low gestation in Sweden}},
  url          = {{http://dx.doi.org/10.1017/exp.2022.4}},
  doi          = {{10.1017/exp.2022.4}},
  volume       = {{3}},
  year         = {{2022}},
}