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Predicting undetected glaucoma according to age and IOP : a prediction model developed from a primarily European-derived population

Oskarsdottir, Sigridur E. LU ; Heijl, Anders LU and Bengtsson, Boel LU (2019) In Acta Ophthalmologica 97(4). p.422-426
Abstract

Purpose: To model prediction of undetected glaucoma in a predominantly white population, based on intraocular pressure (IOP) and subject age. Methods: In 1992–1997, a population screening for glaucoma was performed at Malmö University Hospital where individuals between 55–79 years of age (n = 46 614) living in Malmö, were invited to a free eye health examination. Recently examined patients were not invited (n = 4117). IOP and age were recorded for all screened subjects. Subjects who screened positive were further examined to establish or reject a glaucoma diagnosis. We performed multiple regression analysis of the combined effect of age and IOP on the likelihood of undetected glaucoma. Results: In all, 32 918 subjects attended the... (More)

Purpose: To model prediction of undetected glaucoma in a predominantly white population, based on intraocular pressure (IOP) and subject age. Methods: In 1992–1997, a population screening for glaucoma was performed at Malmö University Hospital where individuals between 55–79 years of age (n = 46 614) living in Malmö, were invited to a free eye health examination. Recently examined patients were not invited (n = 4117). IOP and age were recorded for all screened subjects. Subjects who screened positive were further examined to establish or reject a glaucoma diagnosis. We performed multiple regression analysis of the combined effect of age and IOP on the likelihood of undetected glaucoma. Results: In all, 32 918 subjects attended the screening (77.5% of invited), 22 218 women and 11 700 men, while 9579 refrained from participation. Glaucoma was diagnosed in 406 subjects. The proportion of subjects with glaucoma increased exponentially with increasing IOP and older age. Still, the majority of subjects with glaucoma (57%) had ≤IOP 21 mmHg. The predicted rate of undetected glaucoma was low, <5%, for subjects with IOP <25 mmHg, but rose rapidly with higher IOP, reaching 81% in the group with IOP >35 mmHg and age 75–79 years. The model fit well to the data (R2 = 0.97). Conclusion: We created a model estimating the combined effect of IOP and age on the likelihood of undetected glaucoma. The model may facilitate case-finding in European-derived populations. Despite the important impact of IOP on the risk of glaucoma, a large proportion of subjects with undetected glaucoma had IOP ≤ 21 mmHg.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
age, glaucoma, IOP, prediction, screening, undetected
in
Acta Ophthalmologica
volume
97
issue
4
pages
422 - 426
publisher
Wiley-Blackwell
external identifiers
  • scopus:85054926405
ISSN
1755-375X
DOI
10.1111/aos.13941
language
English
LU publication?
yes
id
a7e8c72a-908f-4bfc-a1bb-d5c01d1df277
date added to LUP
2018-11-06 12:19:58
date last changed
2019-05-27 18:28:19
@article{a7e8c72a-908f-4bfc-a1bb-d5c01d1df277,
  abstract     = {<p>Purpose: To model prediction of undetected glaucoma in a predominantly white population, based on intraocular pressure (IOP) and subject age. Methods: In 1992–1997, a population screening for glaucoma was performed at Malmö University Hospital where individuals between 55–79 years of age (n = 46 614) living in Malmö, were invited to a free eye health examination. Recently examined patients were not invited (n = 4117). IOP and age were recorded for all screened subjects. Subjects who screened positive were further examined to establish or reject a glaucoma diagnosis. We performed multiple regression analysis of the combined effect of age and IOP on the likelihood of undetected glaucoma. Results: In all, 32 918 subjects attended the screening (77.5% of invited), 22 218 women and 11 700 men, while 9579 refrained from participation. Glaucoma was diagnosed in 406 subjects. The proportion of subjects with glaucoma increased exponentially with increasing IOP and older age. Still, the majority of subjects with glaucoma (57%) had ≤IOP 21 mmHg. The predicted rate of undetected glaucoma was low, &lt;5%, for subjects with IOP &lt;25 mmHg, but rose rapidly with higher IOP, reaching 81% in the group with IOP &gt;35 mmHg and age 75–79 years. The model fit well to the data (R<sup>2</sup> = 0.97). Conclusion: We created a model estimating the combined effect of IOP and age on the likelihood of undetected glaucoma. The model may facilitate case-finding in European-derived populations. Despite the important impact of IOP on the risk of glaucoma, a large proportion of subjects with undetected glaucoma had IOP ≤ 21 mmHg.</p>},
  author       = {Oskarsdottir, Sigridur E. and Heijl, Anders and Bengtsson, Boel},
  issn         = {1755-375X},
  keyword      = {age,glaucoma,IOP,prediction,screening,undetected},
  language     = {eng},
  number       = {4},
  pages        = {422--426},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica},
  title        = {Predicting undetected glaucoma according to age and IOP : a prediction model developed from a primarily European-derived population},
  url          = {http://dx.doi.org/10.1111/aos.13941},
  volume       = {97},
  year         = {2019},
}