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Vitamin K and its Role in Diabetic Vascular Complications and Low-Grade Inflammation

Dahlberg, Sofia and Schött, Ulf LU (2018) In Journal of Diabetes and Treatment 2018(1).
Abstract (Swedish)
This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type 2 diabetic patients, the extent of artery calcification correlates to levels of the uncarboxylated Gla protein MGP, and supplementation with vitamin K has been shown to reduce oxidative stress markers as well as metabolic risk markers for diabetes.
Abstract
This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type 2 diabetic patients, the extent of artery calcification correlates to levels of the uncarboxylated Gla protein MGP, and supplementation with vitamin K has been shown to reduce oxidative stress markers as well as metabolic risk markers for diabetes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Diabetes and Treatment
volume
2018
issue
1
pages
6 pages
ISSN
2574-7568
DOI
language
English
LU publication?
yes
id
a8076424-3979-4835-99aa-57940d27c2f8
alternative location
https://gavinpublishers.com/admin/assets/articles_pdf/1516797089article_pdf158589474.pdf
date added to LUP
2018-02-02 16:10:24
date last changed
2018-05-29 10:19:11
@article{a8076424-3979-4835-99aa-57940d27c2f8,
  abstract     = {This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type 2 diabetic patients, the extent of artery calcification correlates to levels of the uncarboxylated Gla protein MGP, and supplementation with vitamin K has been shown to reduce oxidative stress markers as well as metabolic risk markers for diabetes.},
  articleno    = {JDBT-138},
  author       = {Dahlberg, Sofia and Schött, Ulf},
  issn         = {2574-7568},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {6},
  series       = {Journal of Diabetes and Treatment},
  title        = {Vitamin K and its Role in Diabetic Vascular Complications and Low-Grade Inflammation},
  url          = {http://dx.doi.org/},
  volume       = {2018},
  year         = {2018},
}