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Vitamin K and its Role in Diabetic Vascular Complications and Low-Grade Inflammation

Dahlberg, Sofia and Schött, Ulf LU (2018) In Journal of Diabetes and Treatment 2018(1).
Abstract
This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type 2 diabetic patients, the extent of artery calcification correlates to levels of the uncarboxylated Gla protein MGP, and supplementation with vitamin K has been shown to reduce oxidative stress markers as well as metabolic risk markers for diabetes.
Abstract (Swedish)
This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type 2 diabetic patients, the extent of artery calcification correlates to levels of the uncarboxylated Gla protein MGP, and supplementation with vitamin K has been shown to reduce oxidative stress markers as well as metabolic risk markers for diabetes.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Diabetes and Treatment
volume
2018
issue
1
article number
JDBT-138
pages
6 pages
publisher
Gavin Publishers
ISSN
2574-7568
DOI
10.29011/2574-7568.000038
project
Koagulation vid kirurgi och kritisk sjukdom
language
English
LU publication?
yes
id
a8076424-3979-4835-99aa-57940d27c2f8
alternative location
https://gavinpublishers.com/admin/assets/articles_pdf/1516797089article_pdf158589474.pdf
date added to LUP
2018-02-02 16:10:24
date last changed
2018-11-21 21:37:50
@article{a8076424-3979-4835-99aa-57940d27c2f8,
  abstract     = {{This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Os-teocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type 2 diabetic patients, the extent of artery calcification correlates to levels of the uncarboxylated Gla protein MGP, and supplementation with vitamin K has been shown to reduce oxidative stress markers as well as metabolic risk markers for diabetes.}},
  author       = {{Dahlberg, Sofia and Schött, Ulf}},
  issn         = {{2574-7568}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  publisher    = {{Gavin Publishers}},
  series       = {{Journal of Diabetes and Treatment}},
  title        = {{Vitamin K and its Role in Diabetic Vascular Complications and Low-Grade Inflammation}},
  url          = {{http://dx.doi.org/10.29011/2574-7568.000038}},
  doi          = {{10.29011/2574-7568.000038}},
  volume       = {{2018}},
  year         = {{2018}},
}