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Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer

Fang, Qi; Wang, Xufen; Luo, Guanghua; Yu, Miaomei; Zhang, Xiaoying and Xu, Ning LU (2017) In Anticancer Research 37(9). p.4845-4852
Abstract

Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion:... (More)

Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, CXCL8, Estrogen receptor, Overall survival, Progesterone receptor
in
Anticancer Research
volume
37
issue
9
pages
8 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85029417727
  • wos:000412578200015
ISSN
0250-7005
DOI
10.21873/anticanres.11892
language
English
LU publication?
yes
id
a83849db-449d-4623-9ee1-8676a5eb424d
date added to LUP
2017-10-10 10:30:23
date last changed
2018-01-16 13:22:20
@article{a83849db-449d-4623-9ee1-8676a5eb424d,
  abstract     = {<p>Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.</p>},
  author       = {Fang, Qi and Wang, Xufen and Luo, Guanghua and Yu, Miaomei and Zhang, Xiaoying and Xu, Ning},
  issn         = {0250-7005},
  keyword      = {Breast cancer,CXCL8,Estrogen receptor,Overall survival,Progesterone receptor},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {4845--4852},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer},
  url          = {http://dx.doi.org/10.21873/anticanres.11892},
  volume       = {37},
  year         = {2017},
}