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Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer

Fang, Qi ; Wang, Xufen ; Luo, Guanghua ; Yu, Miaomei ; Zhang, Xiaoying and Xu, Ning LU (2017) In Anticancer research 37(9). p.4845-4852
Abstract

Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion:... (More)

Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, CXCL8, Estrogen receptor, Overall survival, Progesterone receptor
in
Anticancer research
volume
37
issue
9
pages
8 pages
publisher
International Institute of Cancer Research
external identifiers
  • pmid:28870904
  • wos:000412578200015
  • scopus:85029417727
ISSN
0250-7005
DOI
10.21873/anticanres.11892
language
English
LU publication?
yes
id
a83849db-449d-4623-9ee1-8676a5eb424d
date added to LUP
2017-10-10 10:30:23
date last changed
2024-05-27 00:11:14
@article{a83849db-449d-4623-9ee1-8676a5eb424d,
  abstract     = {{<p>Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.</p>}},
  author       = {{Fang, Qi and Wang, Xufen and Luo, Guanghua and Yu, Miaomei and Zhang, Xiaoying and Xu, Ning}},
  issn         = {{0250-7005}},
  keywords     = {{Breast cancer; CXCL8; Estrogen receptor; Overall survival; Progesterone receptor}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{4845--4852}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer}},
  url          = {{http://dx.doi.org/10.21873/anticanres.11892}},
  doi          = {{10.21873/anticanres.11892}},
  volume       = {{37}},
  year         = {{2017}},
}