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Heritability of retinal vascular fractals : A twin study

Vergmann, Anna Stage; Broe, Rebecca; Kessel, Line; Hougaard, Jesper Leth LU ; Möller Christensen, Sören, Sören; Kyvik, Kirsten Ohm; Larsen, Michael; Munch, Inger Christine and Grauslund, Jakob (2017) In Investigative Ophthalmology and Visual Science 58(10). p.3997-4002
Abstract

PURPOSE. To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. METHODS. This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50º, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer’s formula and quantitative genetic models were used to determine the genetic component of variation. RESULTS. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that... (More)

PURPOSE. To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. METHODS. This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50º, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer’s formula and quantitative genetic models were used to determine the genetic component of variation. RESULTS. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined. CONCLUSIONS. In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dizogotic, Heredity, Monozygotic, Retinal vascular fractal dimension, Twin
in
Investigative Ophthalmology and Visual Science
volume
58
issue
10
pages
6 pages
publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
external identifiers
  • scopus:85027374014
  • wos:000410940400019
ISSN
0146-0404
DOI
10.1167/iovs.17-22072
language
English
LU publication?
yes
id
a844dbbb-c88e-4204-afd9-05d77e52afdf
date added to LUP
2017-09-04 09:53:36
date last changed
2018-01-16 13:24:37
@article{a844dbbb-c88e-4204-afd9-05d77e52afdf,
  abstract     = {<p>PURPOSE. To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. METHODS. This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50º, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer’s formula and quantitative genetic models were used to determine the genetic component of variation. RESULTS. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h<sup>2</sup> for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined. CONCLUSIONS. In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.</p>},
  author       = {Vergmann, Anna Stage and Broe, Rebecca and Kessel, Line and Hougaard, Jesper Leth and Möller Christensen, Sören, Sören and Kyvik, Kirsten Ohm and Larsen, Michael and Munch, Inger Christine and Grauslund, Jakob},
  issn         = {0146-0404},
  keyword      = {Dizogotic,Heredity,Monozygotic,Retinal vascular fractal dimension,Twin},
  language     = {eng},
  number       = {10},
  pages        = {3997--4002},
  publisher    = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC},
  series       = {Investigative Ophthalmology and Visual Science},
  title        = {Heritability of retinal vascular fractals : A twin study},
  url          = {http://dx.doi.org/10.1167/iovs.17-22072},
  volume       = {58},
  year         = {2017},
}