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Influence of template/functional monomer/cross-linking monomer ratio on particle size and binding properties of molecularly imprinted nanoparticles

Yoshimatsu, Keiichi LU ; Yamazaki, Tomohiko ; Chronakis, Ioannis S. and Ye, Lei LU orcid (2012) In Journal of Applied Polymer Science 124(2). p.1249-1255
Abstract
A series of molecularly imprinted polymer nanoparticles have been synthesized employing various template/functional monomer/crosslinking monomer ratio and characterized in detail to elucidate the correlation between the synthetic conditions used and the properties (e.g., particle size and template binding properties) of the obtained nanoparticles. In brief, the presence of propranolol (template) in the polymerization mixture turned out to be a critical factor on determination of the size as well as the binding properties of the imprinted nanoparticles. The functional monomer/crosslinking monomer ratio significantly affects the binding capability of the imprinted nanoparticles, but its influence on the size of the nanoparticles was found to... (More)
A series of molecularly imprinted polymer nanoparticles have been synthesized employing various template/functional monomer/crosslinking monomer ratio and characterized in detail to elucidate the correlation between the synthetic conditions used and the properties (e.g., particle size and template binding properties) of the obtained nanoparticles. In brief, the presence of propranolol (template) in the polymerization mixture turned out to be a critical factor on determination of the size as well as the binding properties of the imprinted nanoparticles. The functional monomer/crosslinking monomer ratio significantly affects the binding capability of the imprinted nanoparticles, but its influence on the size of the nanoparticles was found to be rather limited. The results obtained provide valuable clues for designing molecularly imprinted nanoparticle preparation in future studies, where fine tuning of particle size and binding properties are required to fit practical applications. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
molecular imprinting, polymer, nanoparticle, propranolol, precipitation, polymerization
in
Journal of Applied Polymer Science
volume
124
issue
2
pages
1249 - 1255
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000298672800043
  • scopus:84855342319
ISSN
1097-4628
DOI
10.1002/app.35150
language
English
LU publication?
yes
id
a85ca239-317a-4789-893b-517b0352b0d1 (old id 2416070)
date added to LUP
2016-04-01 10:21:49
date last changed
2022-01-25 22:30:00
@article{a85ca239-317a-4789-893b-517b0352b0d1,
  abstract     = {{A series of molecularly imprinted polymer nanoparticles have been synthesized employing various template/functional monomer/crosslinking monomer ratio and characterized in detail to elucidate the correlation between the synthetic conditions used and the properties (e.g., particle size and template binding properties) of the obtained nanoparticles. In brief, the presence of propranolol (template) in the polymerization mixture turned out to be a critical factor on determination of the size as well as the binding properties of the imprinted nanoparticles. The functional monomer/crosslinking monomer ratio significantly affects the binding capability of the imprinted nanoparticles, but its influence on the size of the nanoparticles was found to be rather limited. The results obtained provide valuable clues for designing molecularly imprinted nanoparticle preparation in future studies, where fine tuning of particle size and binding properties are required to fit practical applications. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012}},
  author       = {{Yoshimatsu, Keiichi and Yamazaki, Tomohiko and Chronakis, Ioannis S. and Ye, Lei}},
  issn         = {{1097-4628}},
  keywords     = {{molecular imprinting; polymer; nanoparticle; propranolol; precipitation; polymerization}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{1249--1255}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Applied Polymer Science}},
  title        = {{Influence of template/functional monomer/cross-linking monomer ratio on particle size and binding properties of molecularly imprinted nanoparticles}},
  url          = {{http://dx.doi.org/10.1002/app.35150}},
  doi          = {{10.1002/app.35150}},
  volume       = {{124}},
  year         = {{2012}},
}