Copeptin as a marker of atherosclerosis and arteriosclerosis
(2021) In Atherosclerosis 338. p.64-68- Abstract
Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary artery calcium score (CACS), carotid-femoral pulse wave velocity (c-f PWV) and fasting plasma copeptin were measured in 5303 individuals in the Swedish cardiopulmonary bioimage study (SCAPIS). Multivariable logistic regression models were used to analyze the associations between copeptin and high CACS (>100) and high c-f PWV (>10 m/s),... (More)
Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary artery calcium score (CACS), carotid-femoral pulse wave velocity (c-f PWV) and fasting plasma copeptin were measured in 5303 individuals in the Swedish cardiopulmonary bioimage study (SCAPIS). Multivariable logistic regression models were used to analyze the associations between copeptin and high CACS (>100) and high c-f PWV (>10 m/s), respectively. Results: The number of individuals with high CACS and c-f PWV increased across increasing tertile of copeptin (11.7%, 13.3% and 16.3% for CACS and 6.9%, 8.5% and 10.6% for c-f PWV). The top tertile of copeptin was, compared with reference tertile 1, significantly associated with both high CACS and high c-f PWV after adjustment for age, sex, hypertension, diabetes mellitus, HDL, triglycerides, BMI, smoking status, creatinine and high sensitive CRP with an odds ratio (OR) of 1.260 (95% confidence interval (CI): 1.022–1.555) for CACS and OR 1.389 (95% CI: 1.069–1.807) for PWV. Conclusions: Copeptin is associated with both coronary atherosclerosis and increased arterial stiffness in the general population. Our data indicates that copeptin may be a useful marker in the assessment of cardiovascular risk.
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- author
- Schill, Fredrika LU ; Persson, Margaretha LU ; Engström, Gunnar LU ; Melander, Olle LU and Enhörning, Sofia LU
- organization
-
- Cardiovascular Research - Hypertension (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Internal Medicine - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Epidemiology (research group)
- Perinatal and cardiovascular epidemiology (research group)
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Arteriosclerosis, Atherosclerosis, Copeptin, Coronary calcium score, Pulse wave velocity, Vasopressin
- in
- Atherosclerosis
- volume
- 338
- pages
- 64 - 68
- publisher
- Elsevier
- external identifiers
-
- scopus:85119064401
- pmid:34785062
- ISSN
- 0021-9150
- DOI
- 10.1016/j.atherosclerosis.2021.10.012
- project
- MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Authors
- id
- a861248f-d00a-42f3-a801-2127416031a1
- date added to LUP
- 2021-12-03 15:06:37
- date last changed
- 2024-04-20 17:14:34
@article{a861248f-d00a-42f3-a801-2127416031a1, abstract = {{<p>Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary artery calcium score (CACS), carotid-femoral pulse wave velocity (c-f PWV) and fasting plasma copeptin were measured in 5303 individuals in the Swedish cardiopulmonary bioimage study (SCAPIS). Multivariable logistic regression models were used to analyze the associations between copeptin and high CACS (>100) and high c-f PWV (>10 m/s), respectively. Results: The number of individuals with high CACS and c-f PWV increased across increasing tertile of copeptin (11.7%, 13.3% and 16.3% for CACS and 6.9%, 8.5% and 10.6% for c-f PWV). The top tertile of copeptin was, compared with reference tertile 1, significantly associated with both high CACS and high c-f PWV after adjustment for age, sex, hypertension, diabetes mellitus, HDL, triglycerides, BMI, smoking status, creatinine and high sensitive CRP with an odds ratio (OR) of 1.260 (95% confidence interval (CI): 1.022–1.555) for CACS and OR 1.389 (95% CI: 1.069–1.807) for PWV. Conclusions: Copeptin is associated with both coronary atherosclerosis and increased arterial stiffness in the general population. Our data indicates that copeptin may be a useful marker in the assessment of cardiovascular risk.</p>}}, author = {{Schill, Fredrika and Persson, Margaretha and Engström, Gunnar and Melander, Olle and Enhörning, Sofia}}, issn = {{0021-9150}}, keywords = {{Arteriosclerosis; Atherosclerosis; Copeptin; Coronary calcium score; Pulse wave velocity; Vasopressin}}, language = {{eng}}, pages = {{64--68}}, publisher = {{Elsevier}}, series = {{Atherosclerosis}}, title = {{Copeptin as a marker of atherosclerosis and arteriosclerosis}}, url = {{http://dx.doi.org/10.1016/j.atherosclerosis.2021.10.012}}, doi = {{10.1016/j.atherosclerosis.2021.10.012}}, volume = {{338}}, year = {{2021}}, }