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Copeptin as a marker of atherosclerosis and arteriosclerosis

Schill, Fredrika LU orcid ; Persson, Margaretha LU orcid ; Engström, Gunnar LU ; Melander, Olle LU orcid and Enhörning, Sofia LU (2021) In Atherosclerosis 338. p.64-68
Abstract

Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary artery calcium score (CACS), carotid-femoral pulse wave velocity (c-f PWV) and fasting plasma copeptin were measured in 5303 individuals in the Swedish cardiopulmonary bioimage study (SCAPIS). Multivariable logistic regression models were used to analyze the associations between copeptin and high CACS (>100) and high c-f PWV (>10 m/s),... (More)

Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary artery calcium score (CACS), carotid-femoral pulse wave velocity (c-f PWV) and fasting plasma copeptin were measured in 5303 individuals in the Swedish cardiopulmonary bioimage study (SCAPIS). Multivariable logistic regression models were used to analyze the associations between copeptin and high CACS (>100) and high c-f PWV (>10 m/s), respectively. Results: The number of individuals with high CACS and c-f PWV increased across increasing tertile of copeptin (11.7%, 13.3% and 16.3% for CACS and 6.9%, 8.5% and 10.6% for c-f PWV). The top tertile of copeptin was, compared with reference tertile 1, significantly associated with both high CACS and high c-f PWV after adjustment for age, sex, hypertension, diabetes mellitus, HDL, triglycerides, BMI, smoking status, creatinine and high sensitive CRP with an odds ratio (OR) of 1.260 (95% confidence interval (CI): 1.022–1.555) for CACS and OR 1.389 (95% CI: 1.069–1.807) for PWV. Conclusions: Copeptin is associated with both coronary atherosclerosis and increased arterial stiffness in the general population. Our data indicates that copeptin may be a useful marker in the assessment of cardiovascular risk.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arteriosclerosis, Atherosclerosis, Copeptin, Coronary calcium score, Pulse wave velocity, Vasopressin
in
Atherosclerosis
volume
338
pages
64 - 68
publisher
Elsevier
external identifiers
  • scopus:85119064401
  • pmid:34785062
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2021.10.012
project
MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 The Authors
id
a861248f-d00a-42f3-a801-2127416031a1
date added to LUP
2021-12-03 15:06:37
date last changed
2024-04-20 17:14:34
@article{a861248f-d00a-42f3-a801-2127416031a1,
  abstract     = {{<p>Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary artery calcium score (CACS), carotid-femoral pulse wave velocity (c-f PWV) and fasting plasma copeptin were measured in 5303 individuals in the Swedish cardiopulmonary bioimage study (SCAPIS). Multivariable logistic regression models were used to analyze the associations between copeptin and high CACS (&gt;100) and high c-f PWV (&gt;10 m/s), respectively. Results: The number of individuals with high CACS and c-f PWV increased across increasing tertile of copeptin (11.7%, 13.3% and 16.3% for CACS and 6.9%, 8.5% and 10.6% for c-f PWV). The top tertile of copeptin was, compared with reference tertile 1, significantly associated with both high CACS and high c-f PWV after adjustment for age, sex, hypertension, diabetes mellitus, HDL, triglycerides, BMI, smoking status, creatinine and high sensitive CRP with an odds ratio (OR) of 1.260 (95% confidence interval (CI): 1.022–1.555) for CACS and OR 1.389 (95% CI: 1.069–1.807) for PWV. Conclusions: Copeptin is associated with both coronary atherosclerosis and increased arterial stiffness in the general population. Our data indicates that copeptin may be a useful marker in the assessment of cardiovascular risk.</p>}},
  author       = {{Schill, Fredrika and Persson, Margaretha and Engström, Gunnar and Melander, Olle and Enhörning, Sofia}},
  issn         = {{0021-9150}},
  keywords     = {{Arteriosclerosis; Atherosclerosis; Copeptin; Coronary calcium score; Pulse wave velocity; Vasopressin}},
  language     = {{eng}},
  pages        = {{64--68}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Copeptin as a marker of atherosclerosis and arteriosclerosis}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2021.10.012}},
  doi          = {{10.1016/j.atherosclerosis.2021.10.012}},
  volume       = {{338}},
  year         = {{2021}},
}