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Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer

Babic, Ana ; Rosenthal, Michael H ; Sundaresan, Tilak K ; Khalaf, Natalia ; Lee, Valerie ; Brais, Lauren K ; Loftus, Maureen ; Caplan, Leah ; Denning, Sarah and Gurung, Anamol , et al. (2023) In Nature Communications 14(1).
Abstract

Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier cancer detection are not well understood. We quantify skeletal muscle and adipose tissue areas from computed tomography (CT) imaging obtained 2 months to 5 years before cancer diagnosis in 714 pancreatic cancer cases and 1748 matched controls. Adipose tissue loss is identified up to 6 months, and skeletal muscle wasting is identified up to 18 months before the clinical diagnosis of pancreatic cancer and is not present in the matched control population. Tissue losses are of similar magnitude in cases diagnosed with localized compared... (More)

Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier cancer detection are not well understood. We quantify skeletal muscle and adipose tissue areas from computed tomography (CT) imaging obtained 2 months to 5 years before cancer diagnosis in 714 pancreatic cancer cases and 1748 matched controls. Adipose tissue loss is identified up to 6 months, and skeletal muscle wasting is identified up to 18 months before the clinical diagnosis of pancreatic cancer and is not present in the matched control population. Tissue losses are of similar magnitude in cases diagnosed with localized compared with metastatic disease and are not correlated with at-diagnosis circulating levels of CA19-9. Skeletal muscle wasting occurs in the 1-2 years before pancreatic cancer diagnosis and may signal an upcoming diagnosis of pancreatic cancer.

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publishing date
type
Contribution to journal
publication status
published
keywords
Humans, Body Composition, Adipose Tissue/metabolism, Pancreatic Neoplasms/complications, Muscular Atrophy/pathology, Muscle, Skeletal/metabolism, Cachexia/diagnosis
in
Nature Communications
volume
14
issue
1
article number
4317
publisher
Nature Publishing Group
external identifiers
  • scopus:85165291533
  • pmid:37463915
ISSN
2041-1723
DOI
10.1038/s41467-023-40024-3
language
English
LU publication?
no
additional info
© 2023. The Author(s).
id
a8999e8b-7c6a-4bfe-8040-a7db186c8c1d
date added to LUP
2025-05-12 17:11:00
date last changed
2025-07-08 09:54:02
@article{a8999e8b-7c6a-4bfe-8040-a7db186c8c1d,
  abstract     = {{<p>Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier cancer detection are not well understood. We quantify skeletal muscle and adipose tissue areas from computed tomography (CT) imaging obtained 2 months to 5 years before cancer diagnosis in 714 pancreatic cancer cases and 1748 matched controls. Adipose tissue loss is identified up to 6 months, and skeletal muscle wasting is identified up to 18 months before the clinical diagnosis of pancreatic cancer and is not present in the matched control population. Tissue losses are of similar magnitude in cases diagnosed with localized compared with metastatic disease and are not correlated with at-diagnosis circulating levels of CA19-9. Skeletal muscle wasting occurs in the 1-2 years before pancreatic cancer diagnosis and may signal an upcoming diagnosis of pancreatic cancer.</p>}},
  author       = {{Babic, Ana and Rosenthal, Michael H and Sundaresan, Tilak K and Khalaf, Natalia and Lee, Valerie and Brais, Lauren K and Loftus, Maureen and Caplan, Leah and Denning, Sarah and Gurung, Anamol and Harrod, Joanna and Schawkat, Khoschy and Yuan, Chen and Wang, Qiao-Li and Lee, Alice A and Biller, Leah H and Yurgelun, Matthew B and Ng, Kimmie and Nowak, Jonathan A and Aguirre, Andrew J and Bhatia, Sangeeta N and Vander Heiden, Matthew G and Van Den Eeden, Stephen K and Caan, Bette J and Wolpin, Brian M}},
  issn         = {{2041-1723}},
  keywords     = {{Humans; Body Composition; Adipose Tissue/metabolism; Pancreatic Neoplasms/complications; Muscular Atrophy/pathology; Muscle, Skeletal/metabolism; Cachexia/diagnosis}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer}},
  url          = {{http://dx.doi.org/10.1038/s41467-023-40024-3}},
  doi          = {{10.1038/s41467-023-40024-3}},
  volume       = {{14}},
  year         = {{2023}},
}