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Quantification of l-carvone in toothpastes available on the Swedish market

Kroona, Liv; Warfvinge, Gunnar; Isaksson, Marléne LU ; Ahlgren, Camilla; Dahlin, Jakob LU ; Sörensen, Östen LU and Bruze, Magnus LU (2017) In Contact Dermatitis 77(4). p.224-230
Abstract

Background: Toothpastes have widespread use in the population, and contain flavours to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market. Methods: l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were... (More)

Background: Toothpastes have widespread use in the population, and contain flavours to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market. Methods: l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. Results: l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005–0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-carvone were found if limonene was listed on the label. Conclusion: The majority of toothpastes on the Swedish market contain l-carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
contact allergy, contact dermatitis, flavour, fragrances, high-performance liquid chromatography, l-carvone, limonene, oral lichen planus, oral lichenoid lesions, spearmint, toothpastes
in
Contact Dermatitis
volume
77
issue
4
pages
7 pages
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85028733948
  • wos:000409110100005
ISSN
0105-1873
DOI
10.1111/cod.12803
language
English
LU publication?
yes
id
a8cf3480-9856-4e17-a6ff-720ce85c69c0
date added to LUP
2017-10-02 15:28:19
date last changed
2018-01-16 13:20:18
@article{a8cf3480-9856-4e17-a6ff-720ce85c69c0,
  abstract     = {<p>Background: Toothpastes have widespread use in the population, and contain flavours to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market. Methods: l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. Results: l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005–0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-carvone were found if limonene was listed on the label. Conclusion: The majority of toothpastes on the Swedish market contain l-carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.</p>},
  author       = {Kroona, Liv and Warfvinge, Gunnar and Isaksson, Marléne and Ahlgren, Camilla and Dahlin, Jakob and Sörensen, Östen and Bruze, Magnus},
  issn         = {0105-1873},
  keyword      = {contact allergy,contact dermatitis,flavour,fragrances,high-performance liquid chromatography,l-carvone,limonene,oral lichen planus,oral lichenoid lesions,spearmint,toothpastes},
  language     = {eng},
  month        = {10},
  number       = {4},
  pages        = {224--230},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Quantification of l-carvone in toothpastes available on the Swedish market},
  url          = {http://dx.doi.org/10.1111/cod.12803},
  volume       = {77},
  year         = {2017},
}