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Impact of surgical resection rate on survival in gastric cancer : nationwide study

Kung, C. H. ; Jestin Hannan, C. ; Linder, G. ; Johansson, J. LU ; Nilsson, M. ; Hedberg, J. and Lindblad, M. (2021) In BJS Open 5(2).
Abstract

BACKGROUND: There are marked geographical variations in the proportion of patients undergoing resection for gastric cancer. This study investigated the impact of resection rate on survival. METHODS: All patients with potentially curable gastric cancer between 2006 and 2017 were identified from the Swedish National Register of Oesophageal and Gastric Cancer. The annual resection rate was calculated for each county per year. Resection rates in all counties for all years were grouped into tertiles and classified as low, intermediate or high. Survival was analysed using the Cox proportional hazards model. RESULTS: A total of 3465 patients were diagnosed with potentially curable gastric cancer, and 1934 (55.8 per cent) were resected.... (More)

BACKGROUND: There are marked geographical variations in the proportion of patients undergoing resection for gastric cancer. This study investigated the impact of resection rate on survival. METHODS: All patients with potentially curable gastric cancer between 2006 and 2017 were identified from the Swedish National Register of Oesophageal and Gastric Cancer. The annual resection rate was calculated for each county per year. Resection rates in all counties for all years were grouped into tertiles and classified as low, intermediate or high. Survival was analysed using the Cox proportional hazards model. RESULTS: A total of 3465 patients were diagnosed with potentially curable gastric cancer, and 1934 (55.8 per cent) were resected. Resection rates in the low (1261 patients), intermediate (1141) and high (1063) tertiles were 0-50.0, 50.1-62.5 and 62.6-100 per cent respectively. The multivariable Cox analysis revealed better survival for patients diagnosed in counties during years with an intermediate versus low resection rate (hazard ratio (HR) 0.81, 95 per cent c.i. 0.74 to 0.90; P < 0.001) and high versus low resection rate (HR 0.80, 0.73 to 0.88; P < 0.001). CONCLUSION: This national register study showed large regional variation in resection rates for gastric cancer. A higher resection rate appeared to be beneficial with regard to overall survival for the entire population.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BJS Open
volume
5
issue
2
publisher
Wiley
external identifiers
  • scopus:85102906783
  • pmid:33688944
ISSN
2474-9842
DOI
10.1093/bjsopen/zraa017
language
English
LU publication?
yes
id
a8d0d0bb-ad8f-408d-86ec-df5f6557945d
date added to LUP
2021-03-31 09:36:15
date last changed
2024-06-16 11:40:51
@article{a8d0d0bb-ad8f-408d-86ec-df5f6557945d,
  abstract     = {{<p>BACKGROUND: There are marked geographical variations in the proportion of patients undergoing resection for gastric cancer. This study investigated the impact of resection rate on survival. METHODS: All patients with potentially curable gastric cancer between 2006 and 2017 were identified from the Swedish National Register of Oesophageal and Gastric Cancer. The annual resection rate was calculated for each county per year. Resection rates in all counties for all years were grouped into tertiles and classified as low, intermediate or high. Survival was analysed using the Cox proportional hazards model. RESULTS: A total of 3465 patients were diagnosed with potentially curable gastric cancer, and 1934 (55.8 per cent) were resected. Resection rates in the low (1261 patients), intermediate (1141) and high (1063) tertiles were 0-50.0, 50.1-62.5 and 62.6-100 per cent respectively. The multivariable Cox analysis revealed better survival for patients diagnosed in counties during years with an intermediate versus low resection rate (hazard ratio (HR) 0.81, 95 per cent c.i. 0.74 to 0.90; P &lt; 0.001) and high versus low resection rate (HR 0.80, 0.73 to 0.88; P &lt; 0.001). CONCLUSION: This national register study showed large regional variation in resection rates for gastric cancer. A higher resection rate appeared to be beneficial with regard to overall survival for the entire population.</p>}},
  author       = {{Kung, C. H. and Jestin Hannan, C. and Linder, G. and Johansson, J. and Nilsson, M. and Hedberg, J. and Lindblad, M.}},
  issn         = {{2474-9842}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Wiley}},
  series       = {{BJS Open}},
  title        = {{Impact of surgical resection rate on survival in gastric cancer : nationwide study}},
  url          = {{http://dx.doi.org/10.1093/bjsopen/zraa017}},
  doi          = {{10.1093/bjsopen/zraa017}},
  volume       = {{5}},
  year         = {{2021}},
}