N-acetylcysteine administration during the first week of life does not improve lung function in extremely low birth weight infants
Sandberg, K ; Fellman, Vineta LU
; Stigson, L
; Thiringer, K
and Hjalmarson, O
(2004)
In Biology of the Neonate
86(4).
p.275-279
- Abstract
- Oxygen toxicity is thought to be an important factor involved in development of bronchopulmonary dysplasia (BPD) in the very preterm infant. Glutathione (GSH) plays a major role in the antioxidant defense system in the preterm lung and there are theoretical implications that N-acetylcysteine (NAC) treatment could improve its function. The purpose of this study was to investigate whether NAC treatment during the first week of life to preterm infants improved neonatal lung function as a measure of lung injury. The study was part of a multi-center Nordic controlled trial with prophylactic intravenous NAC treatment (16-32 mg/kg/day) for 6 days in newborn infants with birth weights 500-999 g. Lung mechanics, with calculations of compliance and... (More)
- Oxygen toxicity is thought to be an important factor involved in development of bronchopulmonary dysplasia (BPD) in the very preterm infant. Glutathione (GSH) plays a major role in the antioxidant defense system in the preterm lung and there are theoretical implications that N-acetylcysteine (NAC) treatment could improve its function. The purpose of this study was to investigate whether NAC treatment during the first week of life to preterm infants improved neonatal lung function as a measure of lung injury. The study was part of a multi-center Nordic controlled trial with prophylactic intravenous NAC treatment (16-32 mg/kg/day) for 6 days in newborn infants with birth weights 500-999 g. Lung mechanics, with calculations of compliance and resistance of the respiratory system, together with measurements of functional residual capacity and indices of gas mixing efficiency in the lung, were performed in 33 preterm infants (18 received NAC and 15 placebo) before discharge from the NICU. Median (range) gestational age was 25 (24-28) weeks in the NAC-treated infants and 25 (24-29) in the placebo group. Corresponding mean (SD) birth weights were 0.774 (0.11) and 0.761 (0.12) kg respectively. Lung function measurements did not show any significant differences between NAC-treated infants compared to placebo when examined before discharge from the NICU. We conclude that prophylactic NAC treatment to extremely low birth weight infants during the first week of life does not improve lung function at term. Copyright (C) 2004 S. Karger AG, Basel. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/261064
- author
- Sandberg, K
; Fellman, Vineta
LU
; Stigson, L
; Thiringer, K
and Hjalmarson, O
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- lung function testing, in preterm infants, NAC treatment, N-acetylcysteine treatment, antioxidant defense system, bronchopulmonary dysplasia
- in
- Biology of the Neonate
- volume
- 86
- issue
- 4
- pages
- 275 - 279
- publisher
- Karger
- external identifiers
-
- pmid:15297790
- wos:000225100900011
- scopus:8344247129
- pmid:15297790
- ISSN
- 1421-9727
- DOI
- 10.1159/000080089
- language
- English
- LU publication?
- yes
- id
- a9197fce-0c42-4b66-b081-1a33f9c53a3a (old id 261064)
- date added to LUP
- 2016-04-01 12:22:42
- date last changed
- 2022-01-27 02:54:16
@article{a9197fce-0c42-4b66-b081-1a33f9c53a3a,
abstract = {{Oxygen toxicity is thought to be an important factor involved in development of bronchopulmonary dysplasia (BPD) in the very preterm infant. Glutathione (GSH) plays a major role in the antioxidant defense system in the preterm lung and there are theoretical implications that N-acetylcysteine (NAC) treatment could improve its function. The purpose of this study was to investigate whether NAC treatment during the first week of life to preterm infants improved neonatal lung function as a measure of lung injury. The study was part of a multi-center Nordic controlled trial with prophylactic intravenous NAC treatment (16-32 mg/kg/day) for 6 days in newborn infants with birth weights 500-999 g. Lung mechanics, with calculations of compliance and resistance of the respiratory system, together with measurements of functional residual capacity and indices of gas mixing efficiency in the lung, were performed in 33 preterm infants (18 received NAC and 15 placebo) before discharge from the NICU. Median (range) gestational age was 25 (24-28) weeks in the NAC-treated infants and 25 (24-29) in the placebo group. Corresponding mean (SD) birth weights were 0.774 (0.11) and 0.761 (0.12) kg respectively. Lung function measurements did not show any significant differences between NAC-treated infants compared to placebo when examined before discharge from the NICU. We conclude that prophylactic NAC treatment to extremely low birth weight infants during the first week of life does not improve lung function at term. Copyright (C) 2004 S. Karger AG, Basel.}},
author = {{Sandberg, K and Fellman, Vineta and Stigson, L and Thiringer, K and Hjalmarson, O}},
issn = {{1421-9727}},
keywords = {{lung function testing; in preterm infants; NAC treatment; N-acetylcysteine treatment; antioxidant defense system; bronchopulmonary dysplasia}},
language = {{eng}},
number = {{4}},
pages = {{275--279}},
publisher = {{Karger}},
series = {{Biology of the Neonate}},
title = {{N-acetylcysteine administration during the first week of life does not improve lung function in extremely low birth weight infants}},
url = {{http://dx.doi.org/10.1159/000080089}},
doi = {{10.1159/000080089}},
volume = {{86}},
year = {{2004}},
}