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Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

Lindgren, I. LU ; Nenonen, H. LU ; Henic, E. LU ; Bungum, L. LU ; Prahl, A. LU ; Bungum, M. LU ; Leijonhufvud, I. LU ; Huhtaniemi, I. LU ; Yding Andersen, C. and Lundberg Giwercman, Y. LU (2019) In Journal of Assisted Reproduction and Genetics 36(1). p.29-38
Abstract

Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled for IVF during the period 2007–2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2, non-smoking, regular menstruation cycle of 21–35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S... (More)

Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled for IVF during the period 2007–2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2, non-smoking, regular menstruation cycle of 21–35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S polymorphisms. Statistical analyses were done on all completed IVF cycles. Results: Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Conclusions: Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
FSH receptor, In vitro fertilization, Infertility, LHCG receptor, Polymorphism
in
Journal of Assisted Reproduction and Genetics
volume
36
issue
1
pages
29 - 38
publisher
Kluwer
external identifiers
  • scopus:85053533561
ISSN
1058-0468
DOI
10.1007/s10815-018-1318-y
language
English
LU publication?
yes
id
a9298527-dda1-4740-ae91-002b1908ef11
date added to LUP
2018-10-22 12:33:06
date last changed
2019-08-14 04:25:33
@article{a9298527-dda1-4740-ae91-002b1908ef11,
  abstract     = {<p>Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled for IVF during the period 2007–2016. Inclusion criteria were &lt; 40 years of age, body mass index &lt; 30 kg/m<sup>2</sup>, non-smoking, regular menstruation cycle of 21–35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S polymorphisms. Statistical analyses were done on all completed IVF cycles. Results: Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Conclusions: Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.</p>},
  author       = {Lindgren, I. and Nenonen, H. and Henic, E. and Bungum, L. and Prahl, A. and Bungum, M. and Leijonhufvud, I. and Huhtaniemi, I. and Yding Andersen, C. and Lundberg Giwercman, Y.},
  issn         = {1058-0468},
  keyword      = {FSH receptor,In vitro fertilization,Infertility,LHCG receptor,Polymorphism},
  language     = {eng},
  number       = {1},
  pages        = {29--38},
  publisher    = {Kluwer},
  series       = {Journal of Assisted Reproduction and Genetics},
  title        = {Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization},
  url          = {http://dx.doi.org/10.1007/s10815-018-1318-y},
  volume       = {36},
  year         = {2019},
}