A somatic proteoglycan controls Notch-directed germ cell fate
(2021) In Nature Communications 12(1).- Abstract
Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its... (More)
Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.
(Less)
- author
- Gopal, Sandeep
LU
; Amran, Aqilah LU ; Elton, Andre ; Ng, Leelee and Pocock, Roger
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- in
- Nature Communications
- volume
- 12
- issue
- 1
- article number
- 6708
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:34795288
- scopus:85119292386
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-021-27039-4
- language
- English
- LU publication?
- no
- additional info
- © 2021. The Author(s).
- id
- a93408e0-5927-4df0-bcb2-51dd483c4583
- date added to LUP
- 2021-11-22 08:56:00
- date last changed
- 2024-06-15 20:55:57
@article{a93408e0-5927-4df0-bcb2-51dd483c4583, abstract = {{<p>Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.</p>}}, author = {{Gopal, Sandeep and Amran, Aqilah and Elton, Andre and Ng, Leelee and Pocock, Roger}}, issn = {{2041-1723}}, language = {{eng}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Nature Communications}}, title = {{A somatic proteoglycan controls Notch-directed germ cell fate}}, url = {{http://dx.doi.org/10.1038/s41467-021-27039-4}}, doi = {{10.1038/s41467-021-27039-4}}, volume = {{12}}, year = {{2021}}, }