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A somatic proteoglycan controls Notch-directed germ cell fate

Gopal, Sandeep LU orcid ; Amran, Aqilah LU ; Elton, Andre ; Ng, Leelee and Pocock, Roger (2021) In Nature Communications 12(1).
Abstract

Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its... (More)

Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Nature Communications
volume
12
issue
1
article number
6708
publisher
Nature Publishing Group
external identifiers
  • pmid:34795288
  • scopus:85119292386
ISSN
2041-1723
DOI
10.1038/s41467-021-27039-4
language
English
LU publication?
no
additional info
© 2021. The Author(s).
id
a93408e0-5927-4df0-bcb2-51dd483c4583
date added to LUP
2021-11-22 08:56:00
date last changed
2024-06-15 20:55:57
@article{a93408e0-5927-4df0-bcb2-51dd483c4583,
  abstract     = {{<p>Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.</p>}},
  author       = {{Gopal, Sandeep and Amran, Aqilah and Elton, Andre and Ng, Leelee and Pocock, Roger}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{A somatic proteoglycan controls Notch-directed germ cell fate}},
  url          = {{http://dx.doi.org/10.1038/s41467-021-27039-4}},
  doi          = {{10.1038/s41467-021-27039-4}},
  volume       = {{12}},
  year         = {{2021}},
}