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Long-term outcomes of patients with Takayasu arteritis and renal artery involvement : A cohort study

Baldwin, Corisande ; Mohammad, Aladdin J. LU ; Cousins, Claire ; Carette, Simon ; Pagnoux, Christian and Jayne, David (2018) In Rheumatology Advances in Practice 2(2). p.1-7
Abstract


Objective. To describe the long-term outcomes of patients with Takayasu arteritis (TAK) and renal artery involvement (RAI). Methods. A retrospective review of 122 patients with TAK at three tertiary centres in Canada, Sweden and the UK. Data on demographics, laboratory and clinical parameters, medications and angiography findings were collected. Non-renal and renal parameters were compared at baseline and follow- up. Results. A total of 37 patients (30%) with RAI were identified: 18 (49%) with unilateral and 19 (51%) with bilateral RAI. Patients were predominantly female (89%). The median age at diagnosis was 27 years [interquartile range (IQR) 16-38]. The median follow-up... (More)


Objective. To describe the long-term outcomes of patients with Takayasu arteritis (TAK) and renal artery involvement (RAI). Methods. A retrospective review of 122 patients with TAK at three tertiary centres in Canada, Sweden and the UK. Data on demographics, laboratory and clinical parameters, medications and angiography findings were collected. Non-renal and renal parameters were compared at baseline and follow- up. Results. A total of 37 patients (30%) with RAI were identified: 18 (49%) with unilateral and 19 (51%) with bilateral RAI. Patients were predominantly female (89%). The median age at diagnosis was 27 years [interquartile range (IQR) 16-38]. The median follow-up time was 7 years (IQR 2-12). Hypertension was seen in 27 patients (73%) at presentation and 25 (68%) at follow-up. The median estimated glomerular filtration (eGFR) at presentation was 94 and 98 ml/min/1.73 m
2
in those with unilateral and bilateral RAI, respectively. The corresponding median eGFR at follow-up was 101.5 and 104 ml/min/1.73 m
2
, respectively. Three patients at presentation and two at follow-up had an eGFR of < 60 ml/min/1.73 m
2
. Five underwent endovascular intervention and three required surgical interventions. Among the 33 patients with radiologic follow-up, 23 (69%) had persistent RAI and 10 (30%) had resolution of RAI. One (6%) patient with unilateral RAI developed bilateral RAI and three (19%) with bilateral RAI regressed to unilateral RAI. Over time, 23 (62%) patients had stable renal function, 7 (19%) had improvement and 4 had a decline in renal function; no patient developed end-stage renal disease (ESRD). Conclusion. In this series of TAK patients with RAI, long-term non-renal and renal outcomes were favourable. No patient experienced ESRD or died.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Renal, Takayasu arteritis, Vasculitis
in
Rheumatology Advances in Practice
volume
2
issue
2
pages
7 pages
publisher
Oxford University Press
external identifiers
  • scopus:85063183023
DOI
10.1093/rap/rky026
language
English
LU publication?
yes
id
a95762a3-de0f-42d7-9b86-f158a652b56a
date added to LUP
2019-04-05 14:36:24
date last changed
2020-01-13 01:37:07
@article{a95762a3-de0f-42d7-9b86-f158a652b56a,
  abstract     = {<p><br>
                                                         Objective. To describe the long-term outcomes of patients with Takayasu arteritis (TAK) and renal artery involvement (RAI). Methods. A retrospective review of 122 patients with TAK at three tertiary centres in Canada, Sweden and the UK. Data on demographics, laboratory and clinical parameters, medications and angiography findings were collected. Non-renal and renal parameters were compared at baseline and follow- up. Results. A total of 37 patients (30%) with RAI were identified: 18 (49%) with unilateral and 19 (51%) with bilateral RAI. Patients were predominantly female (89%). The median age at diagnosis was 27 years [interquartile range (IQR) 16-38]. The median follow-up time was 7 years (IQR 2-12). Hypertension was seen in 27 patients (73%) at presentation and 25 (68%) at follow-up. The median estimated glomerular filtration (eGFR) at presentation was 94 and 98 ml/min/1.73 m                             <br>
                            <sup>2</sup><br>
                                                          in those with unilateral and bilateral RAI, respectively. The corresponding median eGFR at follow-up was 101.5 and 104 ml/min/1.73 m                             <br>
                            <sup>2</sup><br>
                                                         , respectively. Three patients at presentation and two at follow-up had an eGFR of &lt; 60 ml/min/1.73 m                             <br>
                            <sup>2</sup><br>
                                                         . Five underwent endovascular intervention and three required surgical interventions. Among the 33 patients with radiologic follow-up, 23 (69%) had persistent RAI and 10 (30%) had resolution of RAI. One (6%) patient with unilateral RAI developed bilateral RAI and three (19%) with bilateral RAI regressed to unilateral RAI. Over time, 23 (62%) patients had stable renal function, 7 (19%) had improvement and 4 had a decline in renal function; no patient developed end-stage renal disease (ESRD). Conclusion. In this series of TAK patients with RAI, long-term non-renal and renal outcomes were favourable. No patient experienced ESRD or died.                         <br>
                        </p>},
  author       = {Baldwin, Corisande and Mohammad, Aladdin J. and Cousins, Claire and Carette, Simon and Pagnoux, Christian and Jayne, David},
  language     = {eng},
  month        = {07},
  number       = {2},
  pages        = {1--7},
  publisher    = {Oxford University Press},
  series       = {Rheumatology Advances in Practice},
  title        = {Long-term outcomes of patients with Takayasu arteritis and renal artery involvement : A cohort study},
  url          = {http://dx.doi.org/10.1093/rap/rky026},
  doi          = {10.1093/rap/rky026},
  volume       = {2},
  year         = {2018},
}