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Can heavy metal pollution induce bacterial resistance to heavy metals and antibiotics in soils from an ancient land-mine?

Zhong, Qinmei LU ; Cruz-Paredes, Carla LU orcid ; Zhang, Shirong and Rousk, Johannes LU (2021) In Journal of Hazardous Materials 411.
Abstract

Microbial resistance to antibiotics is a growing challenge to human health. Recent evidence has indicated that antibiotic resistance can be co-selected for by exposure to heavy metals in agricultural soils. It remains unknown if this is a concern in other environments contaminated by metals. We here investigated soil microbial activities, composition and tolerance to heavy metals and antibiotics in a mining soil survey. We found that microbial respiration, growth, and biomass were affected by available metal concentrations. Most of the variation in microbial PLFA composition was explained by differences in heavy metal and pH. Additionally, pollution-induced bacterial community tolerance to toxicants including Cu, Pb, Zn, tetracycline... (More)

Microbial resistance to antibiotics is a growing challenge to human health. Recent evidence has indicated that antibiotic resistance can be co-selected for by exposure to heavy metals in agricultural soils. It remains unknown if this is a concern in other environments contaminated by metals. We here investigated soil microbial activities, composition and tolerance to heavy metals and antibiotics in a mining soil survey. We found that microbial respiration, growth, and biomass were affected by available metal concentrations. Most of the variation in microbial PLFA composition was explained by differences in heavy metal and pH. Additionally, pollution-induced bacterial community tolerance to toxicants including Cu, Pb, Zn, tetracycline and vancomycin was determined. Although only bacterial tolerance to Pb increased with higher levels of metals, the links between bacterial metal tolerance and soil metal concentrations were clear when considered together with previously published reports, suggesting that bacterial metal tolerance were universally elevated in the surveyed soils. The induced levels of heavy metal tolerance coincided with elevated levels of tolerance to vancomycin, but not to tetracycline. Our study showed that heavy metals can co-select for resistance to clinically important antibiotics also in ecosystems without manure input or antibiotic pollution.

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; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotic resistance, Antibiotics, Co-tolerance, Heavy metals, Mining soil
in
Journal of Hazardous Materials
volume
411
article number
124962
publisher
Elsevier
external identifiers
  • pmid:33440279
  • scopus:85099189023
ISSN
0304-3894
DOI
10.1016/j.jhazmat.2020.124962
language
English
LU publication?
yes
id
a98343e9-3367-4308-8e7b-e6e2c7bd9a3b
date added to LUP
2021-01-22 11:09:03
date last changed
2024-05-16 03:16:39
@article{a98343e9-3367-4308-8e7b-e6e2c7bd9a3b,
  abstract     = {{<p>Microbial resistance to antibiotics is a growing challenge to human health. Recent evidence has indicated that antibiotic resistance can be co-selected for by exposure to heavy metals in agricultural soils. It remains unknown if this is a concern in other environments contaminated by metals. We here investigated soil microbial activities, composition and tolerance to heavy metals and antibiotics in a mining soil survey. We found that microbial respiration, growth, and biomass were affected by available metal concentrations. Most of the variation in microbial PLFA composition was explained by differences in heavy metal and pH. Additionally, pollution-induced bacterial community tolerance to toxicants including Cu, Pb, Zn, tetracycline and vancomycin was determined. Although only bacterial tolerance to Pb increased with higher levels of metals, the links between bacterial metal tolerance and soil metal concentrations were clear when considered together with previously published reports, suggesting that bacterial metal tolerance were universally elevated in the surveyed soils. The induced levels of heavy metal tolerance coincided with elevated levels of tolerance to vancomycin, but not to tetracycline. Our study showed that heavy metals can co-select for resistance to clinically important antibiotics also in ecosystems without manure input or antibiotic pollution.</p>}},
  author       = {{Zhong, Qinmei and Cruz-Paredes, Carla and Zhang, Shirong and Rousk, Johannes}},
  issn         = {{0304-3894}},
  keywords     = {{Antibiotic resistance; Antibiotics; Co-tolerance; Heavy metals; Mining soil}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Hazardous Materials}},
  title        = {{Can heavy metal pollution induce bacterial resistance to heavy metals and antibiotics in soils from an ancient land-mine?}},
  url          = {{http://dx.doi.org/10.1016/j.jhazmat.2020.124962}},
  doi          = {{10.1016/j.jhazmat.2020.124962}},
  volume       = {{411}},
  year         = {{2021}},
}