Effects of dextran-linked chloromercuribenzoic acid on insulin release from microdissected pancreatic islets
Åkerstrom, Stig ; Hellman, Bo ; Lernmark, Åker LU
; Lindberg, Bernt
; Söderberg, Monica
and Täljedal, Inge Bert
(1976)
In BBA - General Subjects
451(1).
p.96-105
- Abstract
Insulin release in response to dextran-linked p-chloromercuribenzoic acid was studied in microdissected pancreatic islets of non-inbred ob/ob-mice. No contamination of the dextran-linked mercurial with free chloromercuribenzoic acid was detected before or after the incubation with islets. In comparison with free mercurial, of the same thiol-blocking activity, the dextran-linked compound had a weak insulin-releasing action with a different dose vs. response relationship. The dextran-linked mercurial had no demonstrable effect on the islet content of cyclic AMP. The results support the hypothesis that free organic mercurials mainly stimulate insulin release by blocking thiol groups that are embedded within the β-cell plasma membranes... (More)
Insulin release in response to dextran-linked p-chloromercuribenzoic acid was studied in microdissected pancreatic islets of non-inbred ob/ob-mice. No contamination of the dextran-linked mercurial with free chloromercuribenzoic acid was detected before or after the incubation with islets. In comparison with free mercurial, of the same thiol-blocking activity, the dextran-linked compound had a weak insulin-releasing action with a different dose vs. response relationship. The dextran-linked mercurial had no demonstrable effect on the islet content of cyclic AMP. The results support the hypothesis that free organic mercurials mainly stimulate insulin release by blocking thiol groups that are embedded within the β-cell plasma membranes beneath their surfaces.
(Less)
- author
- Åkerstrom, Stig
; Hellman, Bo
; Lernmark, Åker
LU
; Lindberg, Bernt
; Söderberg, Monica
and Täljedal, Inge Bert
- publishing date
- 1976-11-18
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BBA - General Subjects
- volume
- 451
- issue
- 1
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:795463
- scopus:0017139866
- ISSN
- 0304-4165
- DOI
- 10.1016/0304-4165(76)90261-0
- language
- English
- LU publication?
- no
- id
- a985d39c-6cf9-4945-8c90-87f57985ebfc
- date added to LUP
- 2019-12-12 23:34:27
- date last changed
- 2024-03-13 08:12:16
@article{a985d39c-6cf9-4945-8c90-87f57985ebfc,
abstract = {{<p>Insulin release in response to dextran-linked p-chloromercuribenzoic acid was studied in microdissected pancreatic islets of non-inbred ob/ob-mice. No contamination of the dextran-linked mercurial with free chloromercuribenzoic acid was detected before or after the incubation with islets. In comparison with free mercurial, of the same thiol-blocking activity, the dextran-linked compound had a weak insulin-releasing action with a different dose vs. response relationship. The dextran-linked mercurial had no demonstrable effect on the islet content of cyclic AMP. The results support the hypothesis that free organic mercurials mainly stimulate insulin release by blocking thiol groups that are embedded within the β-cell plasma membranes beneath their surfaces.</p>}},
author = {{Åkerstrom, Stig and Hellman, Bo and Lernmark, Åker and Lindberg, Bernt and Söderberg, Monica and Täljedal, Inge Bert}},
issn = {{0304-4165}},
language = {{eng}},
month = {{11}},
number = {{1}},
pages = {{96--105}},
publisher = {{Elsevier}},
series = {{BBA - General Subjects}},
title = {{Effects of dextran-linked chloromercuribenzoic acid on insulin release from microdissected pancreatic islets}},
url = {{http://dx.doi.org/10.1016/0304-4165(76)90261-0}},
doi = {{10.1016/0304-4165(76)90261-0}},
volume = {{451}},
year = {{1976}},
}