Diurnal variation of flow-mediated vasodilation in healthy premenopausal women
(2000) In American Journal of Physiology - Heart and Circulatory Physiology 279(6). p.2720-2725- Abstract
The present study was designed to test the hypothesis of a diurnal variation of endothelial function. Sixteen healthy, nonsmoking women were studied, each on four occasions during one 24-h period (2:00 PM, 8:00 PM, 2:00 AM, and 8:00 AM). Endothelial function was assessed by ultrasound determinations of flow-mediated vasodilation (FMD%) in the brachial artery. FMD% was contrasted with endothelium-independent vasodilation, i.e., nitroglycerine-induced vasodilation (NTG%). Additionally, plasma concentrations and urinary excretion of nitrate and cGMP were analyzed. FMD% and NTG% displayed diurnal, albeit not parallel, patterns of variation. Whereas FMD% gradually increased from 2:00 PM and peaked at 2:00 AM (means +/- SE: 3.1 +/- 0.4, 4.4... (More)
The present study was designed to test the hypothesis of a diurnal variation of endothelial function. Sixteen healthy, nonsmoking women were studied, each on four occasions during one 24-h period (2:00 PM, 8:00 PM, 2:00 AM, and 8:00 AM). Endothelial function was assessed by ultrasound determinations of flow-mediated vasodilation (FMD%) in the brachial artery. FMD% was contrasted with endothelium-independent vasodilation, i.e., nitroglycerine-induced vasodilation (NTG%). Additionally, plasma concentrations and urinary excretion of nitrate and cGMP were analyzed. FMD% and NTG% displayed diurnal, albeit not parallel, patterns of variation. Whereas FMD% gradually increased from 2:00 PM and peaked at 2:00 AM (means +/- SE: 3.1 +/- 0.4, 4.4 +/- 0.4, 5.1 +/- 0.9, and 3.9 +/- 0.8%), the NTG% demonstrated a nadir at 2:00 AM. Plasma levels and urinary excretion of nitrate and cGMP did not display diurnal variation and no clear association with the variations seen in FMD% and NTG%. This study demonstrates a diurnal variation in both endothelium-dependent and -independent vasodilation in the brachial artery of healthy women. The background and possible implication of such a variation require further studies.
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- author
- Ringqvist, Åsa LU ; Caidahl, Kenneth ; Petersson, Ann-Sofi and Wennmalm, Åke
- publishing date
- 2000-12
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Blood Pressure/physiology, Brachial Artery/physiology, Catecholamines/blood, Circadian Rhythm/physiology, Cyclic GMP/metabolism, Endothelium, Vascular/metabolism, Female, Heart Rate/physiology, Humans, Hydrocortisone/blood, Lipids/blood, Nitrates/metabolism, Nitric Oxide/metabolism, Nitroglycerin/administration & dosage, Premenopause/physiology, Reference Values, Vasodilation/drug effects, Vasodilator Agents/administration & dosage
- in
- American Journal of Physiology - Heart and Circulatory Physiology
- volume
- 279
- issue
- 6
- pages
- 2720 - 2725
- publisher
- American Physiological Society
- external identifiers
-
- scopus:0034536882
- pmid:11087226
- ISSN
- 0363-6135
- DOI
- 10.1152/ajpheart.2000.279.6.H2720
- language
- English
- LU publication?
- no
- id
- a9abdda2-f3e5-462c-9fef-5a3c28c40015
- date added to LUP
- 2022-05-09 14:43:54
- date last changed
- 2024-04-05 17:15:49
@article{a9abdda2-f3e5-462c-9fef-5a3c28c40015,
abstract = {{<p>The present study was designed to test the hypothesis of a diurnal variation of endothelial function. Sixteen healthy, nonsmoking women were studied, each on four occasions during one 24-h period (2:00 PM, 8:00 PM, 2:00 AM, and 8:00 AM). Endothelial function was assessed by ultrasound determinations of flow-mediated vasodilation (FMD%) in the brachial artery. FMD% was contrasted with endothelium-independent vasodilation, i.e., nitroglycerine-induced vasodilation (NTG%). Additionally, plasma concentrations and urinary excretion of nitrate and cGMP were analyzed. FMD% and NTG% displayed diurnal, albeit not parallel, patterns of variation. Whereas FMD% gradually increased from 2:00 PM and peaked at 2:00 AM (means +/- SE: 3.1 +/- 0.4, 4.4 +/- 0.4, 5.1 +/- 0.9, and 3.9 +/- 0.8%), the NTG% demonstrated a nadir at 2:00 AM. Plasma levels and urinary excretion of nitrate and cGMP did not display diurnal variation and no clear association with the variations seen in FMD% and NTG%. This study demonstrates a diurnal variation in both endothelium-dependent and -independent vasodilation in the brachial artery of healthy women. The background and possible implication of such a variation require further studies.</p>}},
author = {{Ringqvist, Åsa and Caidahl, Kenneth and Petersson, Ann-Sofi and Wennmalm, Åke}},
issn = {{0363-6135}},
keywords = {{Adult; Blood Pressure/physiology; Brachial Artery/physiology; Catecholamines/blood; Circadian Rhythm/physiology; Cyclic GMP/metabolism; Endothelium, Vascular/metabolism; Female; Heart Rate/physiology; Humans; Hydrocortisone/blood; Lipids/blood; Nitrates/metabolism; Nitric Oxide/metabolism; Nitroglycerin/administration & dosage; Premenopause/physiology; Reference Values; Vasodilation/drug effects; Vasodilator Agents/administration & dosage}},
language = {{eng}},
number = {{6}},
pages = {{2720--2725}},
publisher = {{American Physiological Society}},
series = {{American Journal of Physiology - Heart and Circulatory Physiology}},
title = {{Diurnal variation of flow-mediated vasodilation in healthy premenopausal women}},
url = {{http://dx.doi.org/10.1152/ajpheart.2000.279.6.H2720}},
doi = {{10.1152/ajpheart.2000.279.6.H2720}},
volume = {{279}},
year = {{2000}},
}