Advanced

A simplified precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids.

Rylander, Lars LU ; Nilsson-Ehle, Peter LU and Hagmar, Lars (2006) In Chemosphere 62(3). p.333-336
Abstract
In order to obtain biomarker values that reflect body burden of persistent organohalogen pollutants (POP), concentrations of lipophilic POP in serum or plasma are generally expressed on a lipid weight basis, and not on a fresh weight basis. There are two different approaches to determine the lipid content in serum and plasma. The gravimetric determination is more expensive, and longer experience is needed as compared with the preferable enzymatic determination. Clinical chemistry laboratories at most hospitals perform enzymatic determinations of cholesterol and triglycerides on a routine basis, whereas analysis of phospholipids is not part of these analyses. In the present study, therefore, we evaluated the association between the sum of... (More)
In order to obtain biomarker values that reflect body burden of persistent organohalogen pollutants (POP), concentrations of lipophilic POP in serum or plasma are generally expressed on a lipid weight basis, and not on a fresh weight basis. There are two different approaches to determine the lipid content in serum and plasma. The gravimetric determination is more expensive, and longer experience is needed as compared with the preferable enzymatic determination. Clinical chemistry laboratories at most hospitals perform enzymatic determinations of cholesterol and triglycerides on a routine basis, whereas analysis of phospholipids is not part of these analyses. In the present study, therefore, we evaluated the association between the sum of measured triglyceride, cholesterol, and phospholipid levels in serum among 617 individuals with the sum of only triglyceride and cholesterol levels. There was a very strong linear association between the sums of serum concentrations of triglycerides and cholesterols and the total lipid concentrations. As much as 97.2% of the variation in total lipid concentrations was explained by the sum of the triglyceride and cholesterol concentrations, with the following regression: Total lipid = 0.9 + 1.3 * (Cholesterol + Triglycerides). Almost identical relationships were recorded in subgroups with men, women and subjects of different age. Thus, total lipid concentrations in blood serum can be accurately estimated by analyzing only cholesterol and triglycerides in the matrix. (c) 2005 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dioxin, PCB, regression, cholesterol, triglycerides, phospholipids
in
Chemosphere
volume
62
issue
3
pages
333 - 336
publisher
Elsevier
external identifiers
  • wos:000234793500001
  • pmid:16005493
  • scopus:28544444360
ISSN
1879-1298
DOI
10.1016/j.chemosphere.2005.04.107
language
English
LU publication?
yes
id
a9bc7843-06b0-46c6-b9cd-3636219b2ea4 (old id 142243)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16005493&dopt=Abstract
date added to LUP
2016-04-01 12:26:52
date last changed
2020-02-12 04:03:53
@article{a9bc7843-06b0-46c6-b9cd-3636219b2ea4,
  abstract     = {In order to obtain biomarker values that reflect body burden of persistent organohalogen pollutants (POP), concentrations of lipophilic POP in serum or plasma are generally expressed on a lipid weight basis, and not on a fresh weight basis. There are two different approaches to determine the lipid content in serum and plasma. The gravimetric determination is more expensive, and longer experience is needed as compared with the preferable enzymatic determination. Clinical chemistry laboratories at most hospitals perform enzymatic determinations of cholesterol and triglycerides on a routine basis, whereas analysis of phospholipids is not part of these analyses. In the present study, therefore, we evaluated the association between the sum of measured triglyceride, cholesterol, and phospholipid levels in serum among 617 individuals with the sum of only triglyceride and cholesterol levels. There was a very strong linear association between the sums of serum concentrations of triglycerides and cholesterols and the total lipid concentrations. As much as 97.2% of the variation in total lipid concentrations was explained by the sum of the triglyceride and cholesterol concentrations, with the following regression: Total lipid = 0.9 + 1.3 * (Cholesterol + Triglycerides). Almost identical relationships were recorded in subgroups with men, women and subjects of different age. Thus, total lipid concentrations in blood serum can be accurately estimated by analyzing only cholesterol and triglycerides in the matrix. (c) 2005 Elsevier Ltd. All rights reserved.},
  author       = {Rylander, Lars and Nilsson-Ehle, Peter and Hagmar, Lars},
  issn         = {1879-1298},
  language     = {eng},
  number       = {3},
  pages        = {333--336},
  publisher    = {Elsevier},
  series       = {Chemosphere},
  title        = {A simplified precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids.},
  url          = {https://lup.lub.lu.se/search/ws/files/2927419/624810.pdf},
  doi          = {10.1016/j.chemosphere.2005.04.107},
  volume       = {62},
  year         = {2006},
}