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TAR-DNA binding protein-43 and alterations in the hippocampus

Rauramaa, Tuomas ; Pikkarainen, Maria ; Englund, Elisabet LU orcid ; Ince, Paul G. ; Jellinger, Kurt ; Paetau, Anders and Alafuzoff, Irina (2011) In Journal of Neural Transmission 118(5). p.683-689
Abstract
Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed... (More)
Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
TAR-DNA binding protein-43, Hyperphosphorylated-tau, p62, Immunohistochemistry, Post-mortem, Hippocampal alterations
in
Journal of Neural Transmission
volume
118
issue
5
pages
683 - 689
publisher
Springer
external identifiers
  • wos:000290542500005
  • scopus:79956214776
  • pmid:21210283
ISSN
0300-9564
DOI
10.1007/s00702-010-0574-5
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
id
a9bd3781-fea7-4253-991b-746e3617176f (old id 1986799)
date added to LUP
2016-04-01 14:35:32
date last changed
2025-04-04 14:03:26
@article{a9bd3781-fea7-4253-991b-746e3617176f,
  abstract     = {{Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.}},
  author       = {{Rauramaa, Tuomas and Pikkarainen, Maria and Englund, Elisabet and Ince, Paul G. and Jellinger, Kurt and Paetau, Anders and Alafuzoff, Irina}},
  issn         = {{0300-9564}},
  keywords     = {{TAR-DNA binding protein-43; Hyperphosphorylated-tau; p62; Immunohistochemistry; Post-mortem; Hippocampal alterations}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{683--689}},
  publisher    = {{Springer}},
  series       = {{Journal of Neural Transmission}},
  title        = {{TAR-DNA binding protein-43 and alterations in the hippocampus}},
  url          = {{http://dx.doi.org/10.1007/s00702-010-0574-5}},
  doi          = {{10.1007/s00702-010-0574-5}},
  volume       = {{118}},
  year         = {{2011}},
}