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Topical diphenylcyclopropenone plus topical 0.5% anthralin versus topical diphenylcyclopropenone alone for the treatment of chronic extensive alopecia areata : A split-scalp, double-blind, controlled study

Thuangtong, Rattapon ; Suvansuthi, Saroj ; Maneeprasopchoke, Pitchaya ; Sukakul, Thanisorn LU orcid ; Techakajornkeart, Rattiya ; Chaweekulrat, Pichanee ; Wongdama, Supisara and Triwongwaranat, Daranporn (2022) In International Journal of Trichology 14(3). p.91-96
Abstract

Background: The combination of diphenylcyclopropenone (DCP) and anthralin may demonstrate synergistic effects in the treatment of chronic extensive alopecia areata (AA).

Objective: The objective of the study was to compare the efficacy of the combination therapy of topical DCP and topical 0.5% anthralin versus topical DCP alone for the treatment of chronic extensive AA.

Materials and Methods: Ten patients were included in the study. Of these, 1, 2, and 7 patients were diagnosed with alopecia totalis, severe AA (>50% hair loss), and alopecia universalis, respectively. For each patient, one side of the scalp was treated with a DCP solution and 0.5% anthralin for 6 months, while the other side was treated with DCP and a... (More)

Background: The combination of diphenylcyclopropenone (DCP) and anthralin may demonstrate synergistic effects in the treatment of chronic extensive alopecia areata (AA).

Objective: The objective of the study was to compare the efficacy of the combination therapy of topical DCP and topical 0.5% anthralin versus topical DCP alone for the treatment of chronic extensive AA.

Materials and Methods: Ten patients were included in the study. Of these, 1, 2, and 7 patients were diagnosed with alopecia totalis, severe AA (>50% hair loss), and alopecia universalis, respectively. For each patient, one side of the scalp was treated with a DCP solution and 0.5% anthralin for 6 months, while the other side was treated with DCP and a cream base for the same duration. The clinical responses were assessed at baseline and then monthly until the end of the 6-month study period using the Severity of Alopecia Tool score. The side effects were evaluated at each follow-up visit.

Results: The difference in the efficacies of the combination treatment and DCP alone was not statistically significant (
P = 0.59). Regarding the side effects, DCP plus 0.5% anthralin caused significantly more excessive dermatitis than DCP alone (7 patients vs. 2 patients;
P = 0.02). Eight patients reported temporary hyperpigmentation at the combination-treatment site, whereas no hyperpigmentation was reported at the DCP-alone site of any patient (
P < 0.001).

Conclusions: The combination of DCP and 0.5% anthralin was not superior to DCP alone for the treatment of chronic extensive AA. An increase in side effects - excessive dermatitis and hyperpigmentation - was observed in the combination-treatment group.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
International Journal of Trichology
volume
14
issue
3
pages
6 pages
publisher
Wolters Kluwer
external identifiers
  • scopus:85131649215
  • pmid:35755959
ISSN
0974-7753
DOI
10.4103/ijt.ijt_72_21
language
English
LU publication?
no
additional info
Copyright: © 2022 International Journal of Trichology.
id
a9cda3fb-3e87-4b21-9017-61d090358f85
date added to LUP
2022-09-06 10:10:23
date last changed
2024-04-18 13:43:55
@article{a9cda3fb-3e87-4b21-9017-61d090358f85,
  abstract     = {{<p>Background: The combination of diphenylcyclopropenone (DCP) and anthralin may demonstrate synergistic effects in the treatment of chronic extensive alopecia areata (AA).</p><p>Objective: The objective of the study was to compare the efficacy of the combination therapy of topical DCP and topical 0.5% anthralin versus topical DCP alone for the treatment of chronic extensive AA.</p><p>Materials and Methods: Ten patients were included in the study. Of these, 1, 2, and 7 patients were diagnosed with alopecia totalis, severe AA (&gt;50% hair loss), and alopecia universalis, respectively. For each patient, one side of the scalp was treated with a DCP solution and 0.5% anthralin for 6 months, while the other side was treated with DCP and a cream base for the same duration. The clinical responses were assessed at baseline and then monthly until the end of the 6-month study period using the Severity of Alopecia Tool score. The side effects were evaluated at each follow-up visit.</p><p>Results: The difference in the efficacies of the combination treatment and DCP alone was not statistically significant (<br>
 P = 0.59). Regarding the side effects, DCP plus 0.5% anthralin caused significantly more excessive dermatitis than DCP alone (7 patients vs. 2 patients; <br>
 P = 0.02). Eight patients reported temporary hyperpigmentation at the combination-treatment site, whereas no hyperpigmentation was reported at the DCP-alone site of any patient (<br>
 P &lt; 0.001).<br>
 </p><p>Conclusions: The combination of DCP and 0.5% anthralin was not superior to DCP alone for the treatment of chronic extensive AA. An increase in side effects - excessive dermatitis and hyperpigmentation - was observed in the combination-treatment group.</p>}},
  author       = {{Thuangtong, Rattapon and Suvansuthi, Saroj and Maneeprasopchoke, Pitchaya and Sukakul, Thanisorn and Techakajornkeart, Rattiya and Chaweekulrat, Pichanee and Wongdama, Supisara and Triwongwaranat, Daranporn}},
  issn         = {{0974-7753}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{91--96}},
  publisher    = {{Wolters Kluwer}},
  series       = {{International Journal of Trichology}},
  title        = {{Topical diphenylcyclopropenone plus topical 0.5% anthralin versus topical diphenylcyclopropenone alone for the treatment of chronic extensive alopecia areata : A split-scalp, double-blind, controlled study}},
  url          = {{http://dx.doi.org/10.4103/ijt.ijt_72_21}},
  doi          = {{10.4103/ijt.ijt_72_21}},
  volume       = {{14}},
  year         = {{2022}},
}