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In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone

van der Valk, Eline S. ; van der Voorn, Bibian ; Iyer, Anand M. ; van den Berg, Sjoerd A.A. ; Savas, Mesut ; de Rijke, Yolanda B. ; van den Akker, Erica L.T. ; Melander, Olle LU orcid and van Rossum, Elisabeth F.C. (2020) In European Journal of Endocrinology 183(6). p.669-676
Abstract

Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the hypothalamic-pituitary adrenal axis (HPA axis), we hypothesize that AVP contributes to chronic hypercortisolism in obesity. Objective: To investigate whether copeptin levels are associated with Higher HairF and HairE levels in obesity. Design: A cross-sectional study in 51 adults with obesity (BMI ≥30 kg/m2). Methods: Associations and... (More)

Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the hypothalamic-pituitary adrenal axis (HPA axis), we hypothesize that AVP contributes to chronic hypercortisolism in obesity. Objective: To investigate whether copeptin levels are associated with Higher HairF and HairE levels in obesity. Design: A cross-sectional study in 51 adults with obesity (BMI ≥30 kg/m2). Methods: Associations and interactions between copeptin, HairF, HairE, and cardiometabolic parameters were cross-sectionally analyzed. Results: Copeptin was strongly associated with BMI and waist circumference (WC) (rho = 0.364 and 0.530, P = 0.008 and <0.001, respectively), also after correction for confounders. There were no associations between copeptin and HairF or HairE on a continuous or dichotomized scale, despite correction for confounders. Conclusion: In patients with obesity, AVP seems not a major contributor to the frequently observed high cortisol levels. Other factors which stimulate the HPA axis or affect cortisol synthesis or breakdown may be more important than the influence of AVP on long-term glucocorticoid levels in obesity.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Endocrinology
volume
183
issue
6
pages
8 pages
publisher
Society of the European Journal of Endocrinology
external identifiers
  • scopus:85095461622
  • pmid:33112256
ISSN
1479-683X
DOI
10.1530/EJE-20-0077
language
English
LU publication?
yes
id
a9d2e823-2639-4202-bf29-931538caccdc
date added to LUP
2020-11-13 08:15:48
date last changed
2024-06-12 23:54:50
@article{a9d2e823-2639-4202-bf29-931538caccdc,
  abstract     = {{<p>Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the hypothalamic-pituitary adrenal axis (HPA axis), we hypothesize that AVP contributes to chronic hypercortisolism in obesity. Objective: To investigate whether copeptin levels are associated with Higher HairF and HairE levels in obesity. Design: A cross-sectional study in 51 adults with obesity (BMI ≥30 kg/m2). Methods: Associations and interactions between copeptin, HairF, HairE, and cardiometabolic parameters were cross-sectionally analyzed. Results: Copeptin was strongly associated with BMI and waist circumference (WC) (rho = 0.364 and 0.530, P = 0.008 and &lt;0.001, respectively), also after correction for confounders. There were no associations between copeptin and HairF or HairE on a continuous or dichotomized scale, despite correction for confounders. Conclusion: In patients with obesity, AVP seems not a major contributor to the frequently observed high cortisol levels. Other factors which stimulate the HPA axis or affect cortisol synthesis or breakdown may be more important than the influence of AVP on long-term glucocorticoid levels in obesity.</p>}},
  author       = {{van der Valk, Eline S. and van der Voorn, Bibian and Iyer, Anand M. and van den Berg, Sjoerd A.A. and Savas, Mesut and de Rijke, Yolanda B. and van den Akker, Erica L.T. and Melander, Olle and van Rossum, Elisabeth F.C.}},
  issn         = {{1479-683X}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{669--676}},
  publisher    = {{Society of the European Journal of Endocrinology}},
  series       = {{European Journal of Endocrinology}},
  title        = {{In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone}},
  url          = {{http://dx.doi.org/10.1530/EJE-20-0077}},
  doi          = {{10.1530/EJE-20-0077}},
  volume       = {{183}},
  year         = {{2020}},
}