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Isolation and partial characterization of a low molecular weight trypsin inhibitor from human urine

Fex, G ; Grubb, A LU orcid ; Loeffler, C and Larsson, J (1981) In Biochimica et Biophysica Acta 667(2). p.8-303
Abstract

A low molecular weight glycoprotein which completely inhibited trypsin at a 1 : 1 molar ratio was isolated from human urine. It was generated from a precursor molecule which in turn derived from plasma inter-alpha-trypsin inhibitor. It had one polypeptide chain with a molecular weight of about 20 000 and a high content of half-cystine residues. Its amino-terminal amino-acid sequence was Val-Thr-Glu-Val-Thr-X-Leu-Glu-Asp-.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha-Globulins/metabolism, Amino Acid Sequence, Carbohydrates/analysis, Glycoproteins/urine, Humans, Immunoelectrophoresis, Kidney Tubules, Molecular Weight, Oxidation-Reduction, Proteinuria/urine, Trypsin Inhibitors/isolation & purification
in
Biochimica et Biophysica Acta
volume
667
issue
2
pages
8 - 303
publisher
Elsevier
external identifiers
  • scopus:0019422520
  • pmid:6163474
ISSN
0006-3002
DOI
10.1016/0005-2795(81)90196-3
language
English
LU publication?
yes
id
a9d98647-6341-4ea4-adb6-15f36042f729
date added to LUP
2021-10-21 16:19:40
date last changed
2024-01-12 02:58:28
@article{a9d98647-6341-4ea4-adb6-15f36042f729,
  abstract     = {{<p>A low molecular weight glycoprotein which completely inhibited trypsin at a 1 : 1 molar ratio was isolated from human urine. It was generated from a precursor molecule which in turn derived from plasma inter-alpha-trypsin inhibitor. It had one polypeptide chain with a molecular weight of about 20 000 and a high content of half-cystine residues. Its amino-terminal amino-acid sequence was Val-Thr-Glu-Val-Thr-X-Leu-Glu-Asp-.</p>}},
  author       = {{Fex, G and Grubb, A and Loeffler, C and Larsson, J}},
  issn         = {{0006-3002}},
  keywords     = {{Alpha-Globulins/metabolism; Amino Acid Sequence; Carbohydrates/analysis; Glycoproteins/urine; Humans; Immunoelectrophoresis; Kidney Tubules; Molecular Weight; Oxidation-Reduction; Proteinuria/urine; Trypsin Inhibitors/isolation & purification}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{8--303}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta}},
  title        = {{Isolation and partial characterization of a low molecular weight trypsin inhibitor from human urine}},
  url          = {{http://dx.doi.org/10.1016/0005-2795(81)90196-3}},
  doi          = {{10.1016/0005-2795(81)90196-3}},
  volume       = {{667}},
  year         = {{1981}},
}