Isolation and partial characterization of a low molecular weight trypsin inhibitor from human urine
(1981) In Biochimica et Biophysica Acta 667(2). p.8-303- Abstract
A low molecular weight glycoprotein which completely inhibited trypsin at a 1 : 1 molar ratio was isolated from human urine. It was generated from a precursor molecule which in turn derived from plasma inter-alpha-trypsin inhibitor. It had one polypeptide chain with a molecular weight of about 20 000 and a high content of half-cystine residues. Its amino-terminal amino-acid sequence was Val-Thr-Glu-Val-Thr-X-Leu-Glu-Asp-.
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- author
- Fex, G ; Grubb, A LU ; Loeffler, C and Larsson, J
- organization
- publishing date
- 1981
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alpha-Globulins/metabolism, Amino Acid Sequence, Carbohydrates/analysis, Glycoproteins/urine, Humans, Immunoelectrophoresis, Kidney Tubules, Molecular Weight, Oxidation-Reduction, Proteinuria/urine, Trypsin Inhibitors/isolation & purification
- in
- Biochimica et Biophysica Acta
- volume
- 667
- issue
- 2
- pages
- 8 - 303
- publisher
- Elsevier
- external identifiers
-
- scopus:0019422520
- pmid:6163474
- ISSN
- 0006-3002
- DOI
- 10.1016/0005-2795(81)90196-3
- language
- English
- LU publication?
- yes
- id
- a9d98647-6341-4ea4-adb6-15f36042f729
- date added to LUP
- 2021-10-21 16:19:40
- date last changed
- 2024-01-12 02:58:28
@article{a9d98647-6341-4ea4-adb6-15f36042f729, abstract = {{<p>A low molecular weight glycoprotein which completely inhibited trypsin at a 1 : 1 molar ratio was isolated from human urine. It was generated from a precursor molecule which in turn derived from plasma inter-alpha-trypsin inhibitor. It had one polypeptide chain with a molecular weight of about 20 000 and a high content of half-cystine residues. Its amino-terminal amino-acid sequence was Val-Thr-Glu-Val-Thr-X-Leu-Glu-Asp-.</p>}}, author = {{Fex, G and Grubb, A and Loeffler, C and Larsson, J}}, issn = {{0006-3002}}, keywords = {{Alpha-Globulins/metabolism; Amino Acid Sequence; Carbohydrates/analysis; Glycoproteins/urine; Humans; Immunoelectrophoresis; Kidney Tubules; Molecular Weight; Oxidation-Reduction; Proteinuria/urine; Trypsin Inhibitors/isolation & purification}}, language = {{eng}}, number = {{2}}, pages = {{8--303}}, publisher = {{Elsevier}}, series = {{Biochimica et Biophysica Acta}}, title = {{Isolation and partial characterization of a low molecular weight trypsin inhibitor from human urine}}, url = {{http://dx.doi.org/10.1016/0005-2795(81)90196-3}}, doi = {{10.1016/0005-2795(81)90196-3}}, volume = {{667}}, year = {{1981}}, }