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Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI

Shah, Preya ; Bassett, Danielle S ; Wisse, Laura E M LU orcid ; Detre, John A ; Stein, Joel M ; Yushkevich, Paul A ; Shinohara, Russell T ; Pluta, John B ; Valenciano, Elijah and Daffner, Molly , et al. (2018) In Human Brain Mapping 39(2). p.851-865
Abstract

Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects (n = 31) using both resting state functional MRI and MTL-focused T2-weighted structural MRI at 7 tesla. Ten MTL subregions per hemisphere, including hippocampal subfields and cortical regions of the parahippocampal gyrus, were segmented for each subject using a multi-atlas algorithm. Both structural covariance matrices from... (More)

Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects (n = 31) using both resting state functional MRI and MTL-focused T2-weighted structural MRI at 7 tesla. Ten MTL subregions per hemisphere, including hippocampal subfields and cortical regions of the parahippocampal gyrus, were segmented for each subject using a multi-atlas algorithm. Both structural covariance matrices from correlations of subregion volumes across subjects, and functional connectivity matrices from correlations between subregion BOLD time series were generated. We found a moderate structural and strong functional inter-hemispheric symmetry. Several bilateral hippocampal subregions (CA1, dentate gyrus, and subiculum) emerged as functional network hubs. We also observed that the structural and functional networks naturally separated into two modules closely corresponding to (a) bilateral hippocampal formations, and (b) bilateral extra-hippocampal structures. Finally, we found a significant correlation in structural and functional connectivity (r = 0.25). Our findings represent a comprehensive analysis of network topology of the MTL at the subregion level. We share our data, methods, and findings as a reference for imaging methods and disease-based research.

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publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Brain Mapping/instrumentation, Female, Humans, Magnetic Resonance Imaging/instrumentation, Male, Neural Pathways/anatomy & histology, Organ Size, Rest, Temporal Lobe/anatomy & histology
in
Human Brain Mapping
volume
39
issue
2
pages
851 - 865
publisher
Wiley-Blackwell
external identifiers
  • scopus:85040350742
  • pmid:29159960
ISSN
1065-9471
DOI
10.1002/hbm.23887
language
English
LU publication?
no
additional info
© 2017 Wiley Periodicals, Inc.
id
a9e335a7-9bd0-4d13-85b8-17cdb55c8088
date added to LUP
2024-02-28 14:51:30
date last changed
2024-10-13 19:59:40
@article{a9e335a7-9bd0-4d13-85b8-17cdb55c8088,
  abstract     = {{<p>Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects (n = 31) using both resting state functional MRI and MTL-focused T2-weighted structural MRI at 7 tesla. Ten MTL subregions per hemisphere, including hippocampal subfields and cortical regions of the parahippocampal gyrus, were segmented for each subject using a multi-atlas algorithm. Both structural covariance matrices from correlations of subregion volumes across subjects, and functional connectivity matrices from correlations between subregion BOLD time series were generated. We found a moderate structural and strong functional inter-hemispheric symmetry. Several bilateral hippocampal subregions (CA1, dentate gyrus, and subiculum) emerged as functional network hubs. We also observed that the structural and functional networks naturally separated into two modules closely corresponding to (a) bilateral hippocampal formations, and (b) bilateral extra-hippocampal structures. Finally, we found a significant correlation in structural and functional connectivity (r = 0.25). Our findings represent a comprehensive analysis of network topology of the MTL at the subregion level. We share our data, methods, and findings as a reference for imaging methods and disease-based research.</p>}},
  author       = {{Shah, Preya and Bassett, Danielle S and Wisse, Laura E M and Detre, John A and Stein, Joel M and Yushkevich, Paul A and Shinohara, Russell T and Pluta, John B and Valenciano, Elijah and Daffner, Molly and Wolk, David A and Elliott, Mark A and Litt, Brian and Davis, Kathryn A and Das, Sandhitsu R}},
  issn         = {{1065-9471}},
  keywords     = {{Adult; Brain Mapping/instrumentation; Female; Humans; Magnetic Resonance Imaging/instrumentation; Male; Neural Pathways/anatomy & histology; Organ Size; Rest; Temporal Lobe/anatomy & histology}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{851--865}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Human Brain Mapping}},
  title        = {{Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI}},
  url          = {{http://dx.doi.org/10.1002/hbm.23887}},
  doi          = {{10.1002/hbm.23887}},
  volume       = {{39}},
  year         = {{2018}},
}