Diagnostic value of analysis of cystatin C and protein HC in biological fluids
(1992) In Clinical Nephrology 38(Suppl 1). p.20-527- Abstract
Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological fluids. Its normal level in plasma is 0.8-2.5 mg/l, in cerebrospinal fluid 4-14 mg/l and in urine 0.03-0.3 mg/l. The production rate of cystatin C is remarkably constant and its plasma concentration can therefore be used as a reliable measure of the glomerular filtration rate (GFR). Indeed, the cystatin C plasma concentration is more closely... (More)
Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological fluids. Its normal level in plasma is 0.8-2.5 mg/l, in cerebrospinal fluid 4-14 mg/l and in urine 0.03-0.3 mg/l. The production rate of cystatin C is remarkably constant and its plasma concentration can therefore be used as a reliable measure of the glomerular filtration rate (GFR). Indeed, the cystatin C plasma concentration is more closely correlated to the GFR than the plasma levels of creatinine and all other investigated low molecular weight proteins, including beta 2-microglobulin and retinol binding protein. Protein HC, alias alpha 1-microglobulin, is produced by the liver as a 27 kDa-glycoprotein. It belongs to the lipocalin superfamily of hydrophobic ligand binding proteins and more than 50% of the normal plasma amount of protein HC is present as a high molecular weight HC-IgA complex carrying antibody activity. The plasma concentration of free protein HC is, in contrast to that of HC-IgA, mainly determined by the GFR. The normal values for the plasma concentrations of HC-IgA and free protein HC are 36-620 mg/l and 14-26 mg/l, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
(Less)
- author
- Grubb, A LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alpha-Globulins/analysis, Amino Acid Sequence, Cystatin C, Cystatins/analysis, Cysteine Proteinase Inhibitors/analysis, Glomerular Filtration Rate, Humans, Kidney Diseases/diagnosis, Kidney Function Tests, Leukemia, Myeloid/diagnosis, Lymphoproliferative Disorders/diagnosis, Molecular Sequence Data, Protease Inhibitors/analysis, Reference Values
- in
- Clinical Nephrology
- volume
- 38
- issue
- Suppl 1
- pages
- 20 - 527
- publisher
- Dustri-Verlag
- external identifiers
-
- scopus:0027058414
- pmid:1284235
- ISSN
- 0301-0430
- language
- English
- LU publication?
- yes
- id
- a9e742ba-bc66-4e9c-be3f-4b5016992f34
- alternative location
- https://europepmc.org/article/med/1284235
- date added to LUP
- 2021-10-28 10:10:35
- date last changed
- 2024-03-23 11:51:23
@article{a9e742ba-bc66-4e9c-be3f-4b5016992f34, abstract = {{<p>Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological fluids. Its normal level in plasma is 0.8-2.5 mg/l, in cerebrospinal fluid 4-14 mg/l and in urine 0.03-0.3 mg/l. The production rate of cystatin C is remarkably constant and its plasma concentration can therefore be used as a reliable measure of the glomerular filtration rate (GFR). Indeed, the cystatin C plasma concentration is more closely correlated to the GFR than the plasma levels of creatinine and all other investigated low molecular weight proteins, including beta 2-microglobulin and retinol binding protein. Protein HC, alias alpha 1-microglobulin, is produced by the liver as a 27 kDa-glycoprotein. It belongs to the lipocalin superfamily of hydrophobic ligand binding proteins and more than 50% of the normal plasma amount of protein HC is present as a high molecular weight HC-IgA complex carrying antibody activity. The plasma concentration of free protein HC is, in contrast to that of HC-IgA, mainly determined by the GFR. The normal values for the plasma concentrations of HC-IgA and free protein HC are 36-620 mg/l and 14-26 mg/l, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)</p>}}, author = {{Grubb, A}}, issn = {{0301-0430}}, keywords = {{Alpha-Globulins/analysis; Amino Acid Sequence; Cystatin C; Cystatins/analysis; Cysteine Proteinase Inhibitors/analysis; Glomerular Filtration Rate; Humans; Kidney Diseases/diagnosis; Kidney Function Tests; Leukemia, Myeloid/diagnosis; Lymphoproliferative Disorders/diagnosis; Molecular Sequence Data; Protease Inhibitors/analysis; Reference Values}}, language = {{eng}}, number = {{Suppl 1}}, pages = {{20--527}}, publisher = {{Dustri-Verlag}}, series = {{Clinical Nephrology}}, title = {{Diagnostic value of analysis of cystatin C and protein HC in biological fluids}}, url = {{https://europepmc.org/article/med/1284235}}, volume = {{38}}, year = {{1992}}, }