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Diagnostic value of analysis of cystatin C and protein HC in biological fluids

Grubb, A LU orcid (1992) In Clinical Nephrology 38(Suppl 1). p.20-527
Abstract

Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological fluids. Its normal level in plasma is 0.8-2.5 mg/l, in cerebrospinal fluid 4-14 mg/l and in urine 0.03-0.3 mg/l. The production rate of cystatin C is remarkably constant and its plasma concentration can therefore be used as a reliable measure of the glomerular filtration rate (GFR). Indeed, the cystatin C plasma concentration is more closely... (More)

Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological fluids. Its normal level in plasma is 0.8-2.5 mg/l, in cerebrospinal fluid 4-14 mg/l and in urine 0.03-0.3 mg/l. The production rate of cystatin C is remarkably constant and its plasma concentration can therefore be used as a reliable measure of the glomerular filtration rate (GFR). Indeed, the cystatin C plasma concentration is more closely correlated to the GFR than the plasma levels of creatinine and all other investigated low molecular weight proteins, including beta 2-microglobulin and retinol binding protein. Protein HC, alias alpha 1-microglobulin, is produced by the liver as a 27 kDa-glycoprotein. It belongs to the lipocalin superfamily of hydrophobic ligand binding proteins and more than 50% of the normal plasma amount of protein HC is present as a high molecular weight HC-IgA complex carrying antibody activity. The plasma concentration of free protein HC is, in contrast to that of HC-IgA, mainly determined by the GFR. The normal values for the plasma concentrations of HC-IgA and free protein HC are 36-620 mg/l and 14-26 mg/l, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha-Globulins/analysis, Amino Acid Sequence, Cystatin C, Cystatins/analysis, Cysteine Proteinase Inhibitors/analysis, Glomerular Filtration Rate, Humans, Kidney Diseases/diagnosis, Kidney Function Tests, Leukemia, Myeloid/diagnosis, Lymphoproliferative Disorders/diagnosis, Molecular Sequence Data, Protease Inhibitors/analysis, Reference Values
in
Clinical Nephrology
volume
38
issue
Suppl 1
pages
20 - 527
publisher
Dustri-Verlag
external identifiers
  • scopus:0027058414
  • pmid:1284235
ISSN
0301-0430
language
English
LU publication?
yes
id
a9e742ba-bc66-4e9c-be3f-4b5016992f34
alternative location
https://europepmc.org/article/med/1284235
date added to LUP
2021-10-28 10:10:35
date last changed
2024-03-23 11:51:23
@article{a9e742ba-bc66-4e9c-be3f-4b5016992f34,
  abstract     = {{<p>Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological fluids. Its normal level in plasma is 0.8-2.5 mg/l, in cerebrospinal fluid 4-14 mg/l and in urine 0.03-0.3 mg/l. The production rate of cystatin C is remarkably constant and its plasma concentration can therefore be used as a reliable measure of the glomerular filtration rate (GFR). Indeed, the cystatin C plasma concentration is more closely correlated to the GFR than the plasma levels of creatinine and all other investigated low molecular weight proteins, including beta 2-microglobulin and retinol binding protein. Protein HC, alias alpha 1-microglobulin, is produced by the liver as a 27 kDa-glycoprotein. It belongs to the lipocalin superfamily of hydrophobic ligand binding proteins and more than 50% of the normal plasma amount of protein HC is present as a high molecular weight HC-IgA complex carrying antibody activity. The plasma concentration of free protein HC is, in contrast to that of HC-IgA, mainly determined by the GFR. The normal values for the plasma concentrations of HC-IgA and free protein HC are 36-620 mg/l and 14-26 mg/l, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)</p>}},
  author       = {{Grubb, A}},
  issn         = {{0301-0430}},
  keywords     = {{Alpha-Globulins/analysis; Amino Acid Sequence; Cystatin C; Cystatins/analysis; Cysteine Proteinase Inhibitors/analysis; Glomerular Filtration Rate; Humans; Kidney Diseases/diagnosis; Kidney Function Tests; Leukemia, Myeloid/diagnosis; Lymphoproliferative Disorders/diagnosis; Molecular Sequence Data; Protease Inhibitors/analysis; Reference Values}},
  language     = {{eng}},
  number       = {{Suppl 1}},
  pages        = {{20--527}},
  publisher    = {{Dustri-Verlag}},
  series       = {{Clinical Nephrology}},
  title        = {{Diagnostic value of analysis of cystatin C and protein HC in biological fluids}},
  url          = {{https://europepmc.org/article/med/1284235}},
  volume       = {{38}},
  year         = {{1992}},
}