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Applications of nanodiamonds in the detection and therapy of infectious diseases

Sangiao, Eva Torres LU ; Holban, Alina Maria and Gestal, Mónica Cartelle (2019) In Materials 12(10).
Abstract

We are constantly exposed to infectious diseases, and they cause millions of deaths per year. TheWorld Health Organization (WHO) estimates that antibiotic resistance could cause 10 million deaths per year by 2050. Multidrug-resistant bacteria are the cause of infection in at least one in three people suffering from septicemia. While antibiotics are powerful agents against infectious diseases, the alarming increase in antibiotic resistance is of great concern. Alternatives are desperately needed, and nanotechnology provides a great opportunity to develop novel approaches for the treatment of infectious diseases. One of the most important factors in the prognosis of an infection caused by an antibiotic resistant bacteria is an early and... (More)

We are constantly exposed to infectious diseases, and they cause millions of deaths per year. TheWorld Health Organization (WHO) estimates that antibiotic resistance could cause 10 million deaths per year by 2050. Multidrug-resistant bacteria are the cause of infection in at least one in three people suffering from septicemia. While antibiotics are powerful agents against infectious diseases, the alarming increase in antibiotic resistance is of great concern. Alternatives are desperately needed, and nanotechnology provides a great opportunity to develop novel approaches for the treatment of infectious diseases. One of the most important factors in the prognosis of an infection caused by an antibiotic resistant bacteria is an early and rigorous diagnosis, jointly with the use of novel therapeutic systems that can specifically target the pathogen and limit the selection of resistant strains. Nanodiamonds can be used as antimicrobial agents due to some of their properties including size, shape, and biocompatibility, which make them highly suitable for the development of efficient and tailored nanotherapies, including vaccines or drug delivery systems. In this review, we discuss the beneficial findings made in the nanodiamonds field, focusing on diagnosis and treatment of infectious diseases. We also highlight the innovative platform that nanodiamonds confer for vaccine improvement, drug delivery, and shuttle systems, as well as their role in the generation of faster and more sensitive clinical diagnosis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotic resistance, Diagnosis, Microbiology, Nanodiamonds, Vaccines
in
Materials
volume
12
issue
10
publisher
MDPI AG
external identifiers
  • scopus:85066841910
ISSN
1996-1944
DOI
10.3390/ma12101639
language
English
LU publication?
yes
id
a9f90789-1df7-4ae4-9aa6-1b144db48cba
date added to LUP
2019-07-01 14:33:55
date last changed
2019-07-09 04:51:14
@article{a9f90789-1df7-4ae4-9aa6-1b144db48cba,
  abstract     = {<p>We are constantly exposed to infectious diseases, and they cause millions of deaths per year. TheWorld Health Organization (WHO) estimates that antibiotic resistance could cause 10 million deaths per year by 2050. Multidrug-resistant bacteria are the cause of infection in at least one in three people suffering from septicemia. While antibiotics are powerful agents against infectious diseases, the alarming increase in antibiotic resistance is of great concern. Alternatives are desperately needed, and nanotechnology provides a great opportunity to develop novel approaches for the treatment of infectious diseases. One of the most important factors in the prognosis of an infection caused by an antibiotic resistant bacteria is an early and rigorous diagnosis, jointly with the use of novel therapeutic systems that can specifically target the pathogen and limit the selection of resistant strains. Nanodiamonds can be used as antimicrobial agents due to some of their properties including size, shape, and biocompatibility, which make them highly suitable for the development of efficient and tailored nanotherapies, including vaccines or drug delivery systems. In this review, we discuss the beneficial findings made in the nanodiamonds field, focusing on diagnosis and treatment of infectious diseases. We also highlight the innovative platform that nanodiamonds confer for vaccine improvement, drug delivery, and shuttle systems, as well as their role in the generation of faster and more sensitive clinical diagnosis.</p>},
  articleno    = {1639},
  author       = {Sangiao, Eva Torres and Holban, Alina Maria and Gestal, Mónica Cartelle},
  issn         = {1996-1944},
  keyword      = {Antibiotic resistance,Diagnosis,Microbiology,Nanodiamonds,Vaccines},
  language     = {eng},
  number       = {10},
  publisher    = {MDPI AG},
  series       = {Materials},
  title        = {Applications of nanodiamonds in the detection and therapy of infectious diseases},
  url          = {http://dx.doi.org/10.3390/ma12101639},
  volume       = {12},
  year         = {2019},
}