Parental smoking and development of allergic sensitization from birth to adolescence
(2016) In Allergy 71(2). p.48-239- Abstract
BACKGROUND: The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.
METHODS: We included 3316 children from a birth cohort followed up for 16 years. SHS exposure and symptoms of allergic disease were assessed using repeated parental questionnaires. Serum immunoglobulin E against eight common inhalant and six food allergens was assessed at ages 4, 8, and 16 years with ImmunoCAP. The association between SHS exposure and sensitization was explored... (More)
BACKGROUND: The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.
METHODS: We included 3316 children from a birth cohort followed up for 16 years. SHS exposure and symptoms of allergic disease were assessed using repeated parental questionnaires. Serum immunoglobulin E against eight common inhalant and six food allergens was assessed at ages 4, 8, and 16 years with ImmunoCAP. The association between SHS exposure and sensitization was explored using logistic regression and generalized estimating equations.
RESULTS: Exposure to SHS in infancy without prior exposure in utero was associated with an excess risk of food sensitization at age 4 years (OR 1.47, 95% CI 1.08-2.00), with comparable ORs at ages 8 and 16 years. In longitudinal analyses, an overall association was indicated between SHS in infancy and food sensitization up to age 16 years (OR 1.24, 95% CI 0.98-1.56). Maternal smoking during pregnancy was unrelated to sensitization up to 16 years of age. When sensitization was combined with concurrent symptoms of allergic disease, SHS in infancy was associated with an overall elevated risk of eczema with sensitization (OR 1.62, 95% CI 1.20-2.18).
CONCLUSIONS: SHS exposure in infancy appears to increase the risk of sensitization to food allergens up to age 16 years, as well as eczema in combination with sensitization.
(Less)
- author
- Thacher, J D LU ; Gruzieva, O ; Pershagen, G ; Neuman, Å ; van Hage, M ; Wickman, M ; Kull, I ; Melén, E and Bergström, A
- publishing date
- 2016-02
- type
- Contribution to journal
- publication status
- published
- keywords
- Adolescent, Child, Child, Preschool, Cohort Studies, Female, Follow-Up Studies, Humans, Hypersensitivity/epidemiology, Immunization, Immunoglobulin E/blood, Infant, Infant, Newborn, Male, Maternal Exposure, Odds Ratio, Population Surveillance, Pregnancy, Prenatal Exposure Delayed Effects, Prevalence, Risk, Smoking/adverse effects, Tobacco Smoke Pollution/adverse effects
- in
- Allergy
- volume
- 71
- issue
- 2
- pages
- 48 - 239
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:84955318298
- pmid:26475651
- ISSN
- 1398-9995
- DOI
- 10.1111/all.12792
- language
- English
- LU publication?
- no
- additional info
- © 2015 The Authors. Allergy Published by John Wiley & Sons Ltd.
- id
- aa0d719c-610b-4548-bc51-d709ca45d643
- date added to LUP
- 2023-05-08 10:59:02
- date last changed
- 2024-04-19 21:38:13
@article{aa0d719c-610b-4548-bc51-d709ca45d643,
abstract = {{<p>BACKGROUND: The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.</p><p>METHODS: We included 3316 children from a birth cohort followed up for 16 years. SHS exposure and symptoms of allergic disease were assessed using repeated parental questionnaires. Serum immunoglobulin E against eight common inhalant and six food allergens was assessed at ages 4, 8, and 16 years with ImmunoCAP. The association between SHS exposure and sensitization was explored using logistic regression and generalized estimating equations.</p><p>RESULTS: Exposure to SHS in infancy without prior exposure in utero was associated with an excess risk of food sensitization at age 4 years (OR 1.47, 95% CI 1.08-2.00), with comparable ORs at ages 8 and 16 years. In longitudinal analyses, an overall association was indicated between SHS in infancy and food sensitization up to age 16 years (OR 1.24, 95% CI 0.98-1.56). Maternal smoking during pregnancy was unrelated to sensitization up to 16 years of age. When sensitization was combined with concurrent symptoms of allergic disease, SHS in infancy was associated with an overall elevated risk of eczema with sensitization (OR 1.62, 95% CI 1.20-2.18).</p><p>CONCLUSIONS: SHS exposure in infancy appears to increase the risk of sensitization to food allergens up to age 16 years, as well as eczema in combination with sensitization.</p>}},
author = {{Thacher, J D and Gruzieva, O and Pershagen, G and Neuman, Å and van Hage, M and Wickman, M and Kull, I and Melén, E and Bergström, A}},
issn = {{1398-9995}},
keywords = {{Adolescent; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Humans; Hypersensitivity/epidemiology; Immunization; Immunoglobulin E/blood; Infant; Infant, Newborn; Male; Maternal Exposure; Odds Ratio; Population Surveillance; Pregnancy; Prenatal Exposure Delayed Effects; Prevalence; Risk; Smoking/adverse effects; Tobacco Smoke Pollution/adverse effects}},
language = {{eng}},
number = {{2}},
pages = {{48--239}},
publisher = {{Wiley-Blackwell}},
series = {{Allergy}},
title = {{Parental smoking and development of allergic sensitization from birth to adolescence}},
url = {{http://dx.doi.org/10.1111/all.12792}},
doi = {{10.1111/all.12792}},
volume = {{71}},
year = {{2016}},
}