FMT-PCCT: Hybrid Fluorescence Molecular Tomography-X-Ray Phase-Contrast CT Imaging of Mouse Models
(2014) In IEEE Transactions on Medical Imaging 33(7). p.1434-1446- Abstract
- The implementation of hybrid fluorescencemolecular tomography (FMT) and X-ray computed tomography (CT) has been shown to be a necessary development, not only for combining anatomical with functional and molecular contrast, but also for generating optical images of high accuracy. FMT affords highly sensitive 3-D imaging of fluorescence bio-distribution, but in stand-alone form it offers images of low resolution. It was shown that FMT accuracy significantly improves by considering anatomical priors from CT. Conversely, CT generally suffers from low soft tissue contrast. Therefore utilization of CT data as prior information in FMT inversion is challenging when different internal organs are not clearly differentiated. Instead, we combined... (More)
- The implementation of hybrid fluorescencemolecular tomography (FMT) and X-ray computed tomography (CT) has been shown to be a necessary development, not only for combining anatomical with functional and molecular contrast, but also for generating optical images of high accuracy. FMT affords highly sensitive 3-D imaging of fluorescence bio-distribution, but in stand-alone form it offers images of low resolution. It was shown that FMT accuracy significantly improves by considering anatomical priors from CT. Conversely, CT generally suffers from low soft tissue contrast. Therefore utilization of CT data as prior information in FMT inversion is challenging when different internal organs are not clearly differentiated. Instead, we combined herein FMT with emerging X-ray phase-contrast CT (PCCT). PCCT relies on phase shift differences in tissue to achieve soft tissue contrast superior to conventional CT. We demonstrate for the first time FMT-PCCT imaging of different animal models, where FMT and PCCT scans were performed in vivo and ex vivo, respectively. The results show that FMT-PCCT expands the potential of FMT in imaging lesions with otherwise low or no CT contrast, while retaining the cost benefits of CT and simplicity of hybrid device realizations. The results point to the most accurate FMT performance to date. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4595807
- author
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- contrast imaging, Computed tomography (CT), fluorescence imaging, molecular imaging, phase, tomography
- in
- IEEE Transactions on Medical Imaging
- volume
- 33
- issue
- 7
- pages
- 1434 - 1446
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- external identifiers
-
- wos:000339042300004
- scopus:84903776609
- pmid:24686244
- ISSN
- 1558-254X
- DOI
- 10.1109/TMI.2014.2313405
- language
- English
- LU publication?
- yes
- id
- aa0e4e9e-dd2d-49fc-9997-6763e2b8d4be (old id 4595807)
- date added to LUP
- 2016-04-01 10:28:59
- date last changed
- 2022-04-04 18:35:58
@article{aa0e4e9e-dd2d-49fc-9997-6763e2b8d4be, abstract = {{The implementation of hybrid fluorescencemolecular tomography (FMT) and X-ray computed tomography (CT) has been shown to be a necessary development, not only for combining anatomical with functional and molecular contrast, but also for generating optical images of high accuracy. FMT affords highly sensitive 3-D imaging of fluorescence bio-distribution, but in stand-alone form it offers images of low resolution. It was shown that FMT accuracy significantly improves by considering anatomical priors from CT. Conversely, CT generally suffers from low soft tissue contrast. Therefore utilization of CT data as prior information in FMT inversion is challenging when different internal organs are not clearly differentiated. Instead, we combined herein FMT with emerging X-ray phase-contrast CT (PCCT). PCCT relies on phase shift differences in tissue to achieve soft tissue contrast superior to conventional CT. We demonstrate for the first time FMT-PCCT imaging of different animal models, where FMT and PCCT scans were performed in vivo and ex vivo, respectively. The results show that FMT-PCCT expands the potential of FMT in imaging lesions with otherwise low or no CT contrast, while retaining the cost benefits of CT and simplicity of hybrid device realizations. The results point to the most accurate FMT performance to date.}}, author = {{Mohajerani, Pouyan and Hipp, Alexander and Willner, Marian and Marschner, Mathias and Trajkovic-Arsic, Marija and Ma, Xiaopeng and Burton, Neal C. and Klemm, Uwe and Radrich, Karin and Ermolayev, Vladimir and Tzoumas, Stratis and Siveke, Jens T. and Bech, Martin and Pfeiffer, Franz and Ntziachristos, Vasilis}}, issn = {{1558-254X}}, keywords = {{contrast imaging; Computed tomography (CT); fluorescence imaging; molecular imaging; phase; tomography}}, language = {{eng}}, number = {{7}}, pages = {{1434--1446}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, series = {{IEEE Transactions on Medical Imaging}}, title = {{FMT-PCCT: Hybrid Fluorescence Molecular Tomography-X-Ray Phase-Contrast CT Imaging of Mouse Models}}, url = {{http://dx.doi.org/10.1109/TMI.2014.2313405}}, doi = {{10.1109/TMI.2014.2313405}}, volume = {{33}}, year = {{2014}}, }