Trophic Factor Gene Therapy for Parkinson's Disease
Kordower, Jeffrey H. and Björklund, Anders LU
(2013)
In Movement Disorders
28(1).
p.96-109
- Abstract
- Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological remedies targeting the dopaminergic network are relatively effective at ameliorating motor deficits, especially in the early stages of the disease, but none of these therapies are curative and many generate their own problems. Recent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell line-derived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in... (More)
- Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological remedies targeting the dopaminergic network are relatively effective at ameliorating motor deficits, especially in the early stages of the disease, but none of these therapies are curative and many generate their own problems. Recent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell line-derived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in double-blinded analyses. This work reviews the field of trophic factor gene delivery for PD. (C) 2013 Movement Disorder Society (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3589835
- author
- Kordower, Jeffrey H.
and Björklund, Anders
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Parkinson's disease, GDNF, neurturin, regeneration, neuroprotection
- in
- Movement Disorders
- volume
- 28
- issue
- 1
- pages
- 96 - 109
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000314995300012
- scopus:84873445906
- pmid:23390096
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.25344
- language
- English
- LU publication?
- yes
- id
- aa19885e-4170-46a0-80f2-c9942dc73c13 (old id 3589835)
- date added to LUP
- 2016-04-01 09:56:13
- date last changed
- 2022-05-05 17:00:54
@article{aa19885e-4170-46a0-80f2-c9942dc73c13,
abstract = {{Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological remedies targeting the dopaminergic network are relatively effective at ameliorating motor deficits, especially in the early stages of the disease, but none of these therapies are curative and many generate their own problems. Recent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell line-derived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in double-blinded analyses. This work reviews the field of trophic factor gene delivery for PD. (C) 2013 Movement Disorder Society}},
author = {{Kordower, Jeffrey H. and Björklund, Anders}},
issn = {{0885-3185}},
keywords = {{Parkinson's disease; GDNF; neurturin; regeneration; neuroprotection}},
language = {{eng}},
number = {{1}},
pages = {{96--109}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Movement Disorders}},
title = {{Trophic Factor Gene Therapy for Parkinson's Disease}},
url = {{http://dx.doi.org/10.1002/mds.25344}},
doi = {{10.1002/mds.25344}},
volume = {{28}},
year = {{2013}},
}