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Delineating the cellular pathways of hematopoietic lineage commitment.

Luc, Sidinh LU ; Buza-Vidas, Natalija LU and Jacobsen, Sten Eirik W LU (2008) In Seminars in Immunology 20. p.213-220
Abstract
The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid... (More)
The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Immunology
volume
20
pages
213 - 220
publisher
Elsevier
external identifiers
  • wos:000259536000003
  • pmid:18752972
  • scopus:50849112769
  • pmid:18752972
ISSN
1096-3618
DOI
10.1016/j.smim.2008.07.005
language
English
LU publication?
yes
id
aa397ad9-923b-447c-b78a-5e60f2f30d2b (old id 1222849)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18752972?dopt=Abstract
date added to LUP
2016-04-04 09:31:46
date last changed
2025-10-14 11:59:39
@article{aa397ad9-923b-447c-b78a-5e60f2f30d2b,
  abstract     = {{The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver.}},
  author       = {{Luc, Sidinh and Buza-Vidas, Natalija and Jacobsen, Sten Eirik W}},
  issn         = {{1096-3618}},
  language     = {{eng}},
  pages        = {{213--220}},
  publisher    = {{Elsevier}},
  series       = {{Seminars in Immunology}},
  title        = {{Delineating the cellular pathways of hematopoietic lineage commitment.}},
  url          = {{http://dx.doi.org/10.1016/j.smim.2008.07.005}},
  doi          = {{10.1016/j.smim.2008.07.005}},
  volume       = {{20}},
  year         = {{2008}},
}