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Allergy in severe asthma

Del Giacco, S. R.; Bakirtas, A.; Bel, E.; Custovic, A.; Diamant, Z. LU ; Hamelmann, E.; Heffler, E.; Kalayci, O.; Saglani, S. and Sergejeva, S., et al. (2017) In Allergy: European Journal of Allergy and Clinical Immunology 72(2). p.207-220
Abstract

It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and... (More)

It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.

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organization
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Contribution to journal
publication status
published
subject
keywords
Aetiology, Allergy, Asthma, Atopy, Severity
in
Allergy: European Journal of Allergy and Clinical Immunology
volume
72
issue
2
pages
207 - 220
publisher
Wiley-Blackwell
external identifiers
  • scopus:85006004187
  • wos:000393360900005
ISSN
0105-4538
DOI
10.1111/all.13072
language
English
LU publication?
yes
id
aa73a3ba-e6dd-4de2-9caf-9b5bb605fbf6
date added to LUP
2016-12-29 12:16:20
date last changed
2018-07-08 04:20:16
@article{aa73a3ba-e6dd-4de2-9caf-9b5bb605fbf6,
  abstract     = {<p>It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.</p>},
  author       = {Del Giacco, S. R. and Bakirtas, A. and Bel, E. and Custovic, A. and Diamant, Z. and Hamelmann, E. and Heffler, E. and Kalayci, O. and Saglani, S. and Sergejeva, S. and Seys, S. and Simpson, A. and Bjermer, L.},
  issn         = {0105-4538},
  keyword      = {Aetiology,Allergy,Asthma,Atopy,Severity},
  language     = {eng},
  number       = {2},
  pages        = {207--220},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy: European Journal of Allergy and Clinical Immunology},
  title        = {Allergy in severe asthma},
  url          = {http://dx.doi.org/10.1111/all.13072},
  volume       = {72},
  year         = {2017},
}